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TAK-915 is a potent, selective, and brain-penetrant phosphodiesterase 2A (PDE2A) inhibitor (IC50: 0.61 nM) with >4100-fold selectivity for PDE2A over PDE1A.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
5 mg | $764 | Backorder | |
10 mg | $1,220 | Backorder |
Description | TAK-915 is a potent, selective, and brain-penetrant phosphodiesterase 2A (PDE2A) inhibitor (IC50: 0.61 nM) with >4100-fold selectivity for PDE2A over PDE1A. |
Targets&IC50 | PDE2A:0.61 nM, PDE1A:2497 nM |
In vivo | TAK-915 (1, 3, and 10?mg/kg, p.o.) dose-dependently attenuates the non-selective muscarinic antagonist scopolamine-induced memory deficits in rats. TAK-915 (3 or 10 mg/kg, p.o.) in mice produces a dose-dependent increase in 3',5'-cyclic guanosine monophosphate (cGMP) levels, with significant cGMP increases observed at a dose of 10 mg/kg. TAK-915 (3 mg/kg; p.o.; daily; for 4 days; male F344 rats) treatment significantly reduces escape latency in aged rats in the Morris water maze task [1][2]. |
Molecular Weight | 458.36 |
Formula | C19H18F4N4O5 |
Cas No. | 1476727-50-0 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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