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TD-0212

Catalog No. T13125Cas No. 1073549-10-6

TD-0212 is an orally active dual pharmacology antagonist of angiotensin II type 1 receptor (AT1) and inhibitor of neprilysin (NEP)(pKi of 8.9 for AT1 and a pIC50 of 9.2 for NEP).

TD-0212

TD-0212

Catalog No. T13125Cas No. 1073549-10-6
TD-0212 is an orally active dual pharmacology antagonist of angiotensin II type 1 receptor (AT1) and inhibitor of neprilysin (NEP)(pKi of 8.9 for AT1 and a pIC50 of 9.2 for NEP).
Pack SizePriceAvailabilityQuantity
25 mg$2,72010-14 weeks
50 mg$3,58010-14 weeks
100 mg$4,90010-14 weeks
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Product Introduction

Bioactivity
Description
TD-0212 is an orally active dual pharmacology antagonist of angiotensin II type 1 receptor (AT1) and inhibitor of neprilysin (NEP)(pKi of 8.9 for AT1 and a pIC50 of 9.2 for NEP).
Targets&IC50
NEP:9.2(pIC50), AT1:(pKi)8.9
In vitro
TD-0212 is a AT1/NEP dual inhibitor, with a potentially lower risk of angioedema relative to dual ACE/NEP inhibition.
In vivo
In models of renin-dependent and –independent hypertension, TD-0212 produces blood pressure reductions similar to omapatrilat and combinations of AT1 receptor antagonists and NEP inhibitors .
Chemical Properties
Molecular Weight527.65
FormulaC28H34FN3O4S
Cas No.1073549-10-6
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

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