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TD-0212 is an orally active dual pharmacology antagonist of angiotensin II type 1 receptor (AT1) and inhibitor of neprilysin (NEP)(pKi of 8.9 for AT1 and a pIC50 of 9.2 for NEP).
Pack Size | Price | Availability | Quantity |
---|---|---|---|
25 mg | $2,720 | 10-14 weeks | |
50 mg | $3,580 | 10-14 weeks | |
100 mg | $4,900 | 10-14 weeks |
Description | TD-0212 is an orally active dual pharmacology antagonist of angiotensin II type 1 receptor (AT1) and inhibitor of neprilysin (NEP)(pKi of 8.9 for AT1 and a pIC50 of 9.2 for NEP). |
Targets&IC50 | NEP:9.2(pIC50), AT1:(pKi)8.9 |
In vitro | TD-0212 is a AT1/NEP dual inhibitor, with a potentially lower risk of angioedema relative to dual ACE/NEP inhibition. |
In vivo | In models of renin-dependent and –independent hypertension, TD-0212 produces blood pressure reductions similar to omapatrilat and combinations of AT1 receptor antagonists and NEP inhibitors . |
Molecular Weight | 527.65 |
Formula | C28H34FN3O4S |
Cas No. | 1073549-10-6 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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