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TD-0212 TFA

Catalog No. T13125LCas No. 1073549-11-7

TD-0212 TFA is an orally active dual pharmacology antagonist of angiotensin II type 1 receptor (AT1) and inhibitor of neprilysin (NEP)(pKi of 8.9 for AT1 and a pIC50 of 9.2 for NEP).

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Pack Size	Price	Availability
25 mg	$2,720	10-14 weeks
50 mg	$3,580	10-14 weeks
100 mg	$4,900	10-14 weeks

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Product Introduction

Bioactivity

Description	TD-0212 TFA is an orally active dual pharmacology antagonist of angiotensin II type 1 receptor (AT1) and inhibitor of neprilysin (NEP)(pKi of 8.9 for AT1 and a pIC50 of 9.2 for NEP).
In vitro	TD-0212 provides the enhanced activity of dual AT1/NEP inhibition and may have a lower risk of angioedema than dual ACE/NEP inhibition.
In vivo	In renin-dependent and non-dependent hypertension models, TD-0212 can lower blood pressure, similar to omapatrilat and the combination of AT1 receptor antagonist and NEP inhibitor.

Chemical Properties

Molecular Weight	641.67
Formula	C30H35F4N3O6S
Cas No.	1073549-11-7

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 125 mg/mL (194.80 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.5584 mL	7.7922 mL	15.5843 mL	77.9217 mL
5 mM	0.3117 mL	1.5584 mL	3.1169 mL	15.5843 mL
10 mM	0.1558 mL	0.7792 mL	1.5584 mL	7.7922 mL
20 mM	0.0779 mL	0.3896 mL	0.7792 mL	3.8961 mL
50 mM	0.0312 mL	0.1558 mL	0.3117 mL	1.5584 mL
100 mM	0.0156 mL	0.0779 mL	0.1558 mL	0.7792 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc