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TD-0212 TFA

Name: TD-0212 TFA
Brand: TargetMol
SKU: T13125L
Price: 213 USD
Availability: InStock
Rating: 4.5 (1 reviews)

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Catalog No. T13125LCas No. 1073549-11-7

TD-0212 TFA is an orally active dual pharmacology compound, functioning as an antagonist of the angiotensin II type 1 receptor (AT1) with a pKi of 8.9, and as an inhibitor of neprilysin (NEP) with a pIC50 of 9.2.

TD-0212 TFA

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Catalog No. T13125LCas No. 1073549-11-7

Pack Size	Price	Availability
25 mg	$2,720	10-14 weeks
50 mg	$3,580	10-14 weeks
100 mg	$4,900	10-14 weeks

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Product Introduction

Bioactivity

Description	TD-0212 TFA is an orally active dual pharmacology compound, functioning as an antagonist of the angiotensin II type 1 receptor (AT1) with a pKi of 8.9, and as an inhibitor of neprilysin (NEP) with a pIC50 of 9.2.
Targets&IC50	NEP:9.2(pIC50), AT1:(pKi)8.9
In vitro	TD-0212 exhibits improved dual AT1/NEP inhibition activity and may present a reduced angioedema risk compared to dual ACE/NEP inhibition.
In vivo	In renin-dependent and non-dependent hypertension models, TD-0212 can lower blood pressure, similar to omapatrilat and the combination of AT1 receptor antagonist and NEP inhibitor.

Chemical Properties

Molecular Weight	641.67
Formula	C₃₀H₃₅F₄N₃O₆S
Cas No.	1073549-11-7
Relative Density.	1.31g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

DMSO: 125 mg/mL (194.80 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.5584 mL	7.7922 mL	15.5843 mL	77.9217 mL
5 mM	0.3117 mL	1.5584 mL	3.1169 mL	15.5843 mL
10 mM	0.1558 mL	0.7792 mL	1.5584 mL	7.7922 mL
20 mM	0.0779 mL	0.3896 mL	0.7792 mL	3.8961 mL
50 mM	0.0312 mL	0.1558 mL	0.3117 mL	1.5584 mL
100 mM	0.0156 mL	0.0779 mL	0.1558 mL	0.7792 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

TD0212 TFATD 0212 TFATD-0212 TFA