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TP-472

Catalog No. T13190 CAS 2079895-62-6

TP-472 is a selective inhibitor of BRD9 (Kd: 33 nM).

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TP-472, CAS 2079895-62-6

Pack Size	Availability	Price/USD	Quantity
1 mg	4-5 weeks	$ 78.00
5 mg	4-5 weeks	$ 348.00

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This compound is a customized synthesis product. We have a strong synthesis team with excellent synthesis technology and capabilities. However, due to various objective factors, there is a low probability that the synthesis will not be successful. If you need to learn more, please feel free to consult us, we will serve you wholeheartedly.

Biological Description

Chemical Properties

Storage & Solubility Information

Description	TP-472 is a selective inhibitor of BRD9 (Kd: 33 nM).
Targets&IC50	BRD9:(kd)33 nM
In vitro	TP-472 has a high potency for BRD9 with Kd of 33 nM and BRD7 with Kd of 0.34 μM, with >30-fold selectivity over other Brds[1]. TP-472 (1 μM, 3 μM; 24-216 hours) yields concentration-dependent growth defects in ESCs[2].

Molecular Weight	333.38
Formula	C20H19N3O2
CAS No.	2079895-62-6

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Moustakim M, et al. Chemical probes and inhibitors of bromodomains outside the BET family. Medchemcomm. 2016 Dec 7;7(12):2246-2264. 2. Gatchalian J, et al. A non-canonical BRD9-containing BAF chromatin remodeling complex regulates naive pluripotency in mouse embryonic stem cells. Nat Commun. 2018 Dec 3;9(1):5139.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

TP-472 2079895-62-6 Chromatin/Epigenetic Epigenetic Reader Domain TP472 TP 472 inhibitor inhibit

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