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Thioflosulide
Thioflosulide (L-745337) is a selective and potent COX2 inhibitor with an IC50 of 2.3 nM, exhibiting anti-inflammatory activity for the study of gastric ulcers.
Catalog No. T15687Cas No. 158205-05-1
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Purity:100%
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Thioflosulide
Catalog No. T15687Alias L-745337Cas No. 158205-05-1
Thioflosulide (L-745337) is a selective and potent COX2 inhibitor with an IC50 of 2.3 nM, exhibiting anti-inflammatory activity for the study of gastric ulcers.
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose. | Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $700 | 8-10 weeks | |
| 5 mg | $1,800 | 8-10 weeks |
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CitedProduct Introduction
Bioactivity
Chemical Properties
| Description | Thioflosulide (L-745337) is a selective and potent COX2 inhibitor with an IC50 of 2.3 nM, exhibiting anti-inflammatory activity for the study of gastric ulcers. |
| Targets&IC50 | COX-2:2.3 nM |
| In vivo | In a rat model of postoperative pain, Thioflosulide (L-745337) coadministered intrathecally (40-80 μg) with intrathecal morphine (0.5 nmol) increases withdrawal thresholds dose-dependently. Adding 80 μg of Thioflosulide to 1 nmol of morphine produces a greater antiallodynic effect than morphine at twice the dose. When combined with intrathecal morphine, subcutaneous administration of Thioflosulide (0-30 mg/kg) results in the same antiallodynic response as morphine alone. Thioflosulide also exhibits anti-inflammatory activity, with an effective dose of 0.4 mg/kg and a maximal anti-inflammation dose of 5 mg/kg in arthritic rats. |
| Alias | L-745337 |
| Molecular Weight | 369.41 |
| Formula | C16H13F2NO3S2 |
| Cas No. | 158205-05-1 |
Storage & Solubility Information
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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