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Tirzepatide

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Purity:99.99%

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COA LCMS HPLC MS

Tirzepatide

Catalog No. TP1111Cas No. 2023788-19-2

Tirzepatide (LY-3298176) is a dual agonist of glucose-dependent polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) receptor with neuroprotective activity for the study of diabetes and obesity.

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Pack Size	Price	Availability
1 mg	$266	In Stock
5 mg	$698	In Stock
10 mg	$993	In Stock
25 mg	$1,470	In Stock
50 mg	$1,990	In Stock
100 mg	$2,680	In Stock

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Product Introduction

Bioactivity

Description	Tirzepatide (LY-3298176) is a dual agonist of glucose-dependent polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) receptor with neuroprotective activity for the study of diabetes and obesity.
In vitro	In SHSY5Y cells, treatment with Tirzepatide (0-0.4 μM; 7 days) upregulated the mRNA expression and protein levels of both CREB and BDNF, while increasing the protein levels of Bcl-2, pAkt, MAP2, GAP43, AGBL4, GLUT4, and SORBS1[1].
In vivo	In diet-induced obese (DIO) mice, treatment with Tirzepatide (10 nM/kg; subcutaneous injection) resulted in reduced body weight and food consumption, as well as decreased levels of glucose, insulin, leptin, and C-peptide[2].
Alias	LY-3298176

Chemical Properties

Molecular Weight	4813.45
Formula	C225H348N48O68
Cas No.	2023788-19-2

Storage & Solubility Information

Storage

keep away from moisture,store at low temperature Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 100 mg/mL (20.78 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	0.2078 mL	1.0388 mL	2.0775 mL	10.3876 mL
5 mM	0.0416 mL	0.2078 mL	0.4155 mL	2.0775 mL
10 mM	0.0208 mL	0.1039 mL	0.2078 mL	1.0388 mL
20 mM	0.0104 mL	0.0519 mL	0.1039 mL	0.5194 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

Dose Conversion

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Tech Support

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