Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Verrucarin A (Muconomycin A) is a Type D macrocyclic mycotoxin. Verrucarin A (VA), a protein synthesis inhibitor, derived from the pathogen fungus Myrothecium verrucaria, inhibits growth of leukemia cell lines and activates caspases and apoptosis and inflammatory signaling in macrophages. Verrucarin A effectively increased the phosphorylation of p38 MAPK and diminished the phosphorylation of ERK/Akt. Verrucarin A caused cell cycle deregulation through the induction of p21 and p53 [1] [2].
Pack Size | Availability | Price/USD | Quantity |
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1 mg | 35 days | $ 293.00 |
Description | Verrucarin A (Muconomycin A) is a Type D macrocyclic mycotoxin. Verrucarin A (VA), a protein synthesis inhibitor, derived from the pathogen fungus Myrothecium verrucaria, inhibits growth of leukemia cell lines and activates caspases and apoptosis and inflammatory signaling in macrophages. Verrucarin A effectively increased the phosphorylation of p38 MAPK and diminished the phosphorylation of ERK/Akt. Verrucarin A caused cell cycle deregulation through the induction of p21 and p53 [1] [2]. |
In vitro | Verrucarin A, at concentrations ranging from 0 to 0.6 μM/ml over 24 to 48 hours, exhibits a time- and dose-dependent inhibition of growth in the MCF-7 human breast cancer cell line. It effectively raises the levels of reactive oxygen species (ROS), which leads to a reduction in mitochondrial membrane potential (Δψm). This reduction triggers an increase in the Bax/Bcl-2 ratio, ensuing the release of cytochrome c, activation of caspases, PARP degradation, and ultimately inducing apoptosis. The cell viability assay further substantiates these findings, demonstrating significant growth inhibition of MCF-7 cells in a dose- and time-responsive manner, with IC50 values of 0.41 and 0.29 μM/ml for 24- and 48-hour treatment periods, respectively. |
Molecular Weight | 502.55 |
Formula | C27H34O9 |
CAS No. | 3148-09-2 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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Verrucarin A 3148-09-2 inhibitor inhibit