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(D)-PPA 1 TFA
Catalog No. T78222
(D)-PPA 1 TFA, a hydrolysis-resistant D-peptide antagonist, is a potent PD-1/PD-L1 inhibitor with an affinity for PD-1 of 0.51 μM, demonstrating efficacy both in vitro and in vivo [1].
(D)-PPA 1 TFA
(D)-PPA 1 TFA
Catalog No. T78222
(D)-PPA 1 TFA, a hydrolysis-resistant D-peptide antagonist, is a potent PD-1/PD-L1 inhibitor with an affinity for PD-1 of 0.51 μM, demonstrating efficacy both in vitro and in vivo [1].
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 5 mg | Inquiry | Backorder | |
| 50 mg | Inquiry | Backorder |
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Product Introduction
Bioactivity
Chemical Properties
| Description | (D)-PPA 1 TFA, a hydrolysis-resistant D-peptide antagonist, is a potent PD-1/PD-L1 inhibitor with an affinity for PD-1 of 0.51 μM, demonstrating efficacy both in vitro and in vivo [1]. |
| In vitro | (D)-PPA 1 TFA at concentrations of (0.2 mg/mL, 1.0 mg/mL) inhibits the interaction between PD-1 and PD-L1 at 1.0 mg/mL [1]. (D)-PPA 1 (3.125-100 μM; 24 h, 48 h) does not directly kill tumor cells and has no effect on the growth of CT26 cells [1]. |
| In vivo | (D)-PPA 1 TFA administered at a dose of 2 mg/kg through subcutaneous or intraperitoneal injection once daily for seven consecutive days inhibited the growth of CT26 tumors in mice [1]. Additionally, a single intravenous dose of 40 μg/mouse in 200 μL demonstrated the capability to target tumor tissue in CT26 tumor-bearing mice [1]. |
| Molecular Weight | 1669.67 |
| Formula | C72H99F3N20O23 |
Storage & Solubility Information
| Storage | Shipping with blue ice. |
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For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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