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Camrelizumab

Catalog No. T37535 CAS 1798286-48-2

Synonyms: SHR-1210

Camrelizumab (SHR-1210) is a human IgG4-κ monoclonal antibody with high affinity and directed against PD-1.Camrelizumab binds PD-1 with a binding affinity of up to 3 nM and is inhibitory to PD-1/PD-L1 with an IC50 of 0.70 nM.Camrelizumab exhibits anti-tumor activity and is well tolerated in the study cancers including NSC-LC, ESCC, Hodgkin's lymphoma and advanced HCC.

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Camrelizumab, CAS 1798286-48-2

Pack Size	Availability	Price/USD	Quantity
5 mg	In stock	$ 575.00
10 mg	Inquiry	$ 823.00

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Purity: 98.6%

Biological Description

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Description	Camrelizumab (SHR-1210) is a human IgG4-κ monoclonal antibody with high affinity and directed against PD-1.Camrelizumab binds PD-1 with a binding affinity of up to 3 nM and is inhibitory to PD-1/PD-L1 with an IC50 of 0.70 nM.Camrelizumab exhibits anti-tumor activity and is well tolerated in the study cancers including NSC-LC, ESCC, Hodgkin's lymphoma and advanced HCC.
Targets&IC50	PD-1/PD-L1:0.70 nM (IC50)
In vitro	In a T cell proliferation assay using tuberculin treated peripheral blood mononuclear cells, Camrelizumab induces a T cell proliferation at an EC50 of 0.11 nM. In a similar assay measuring IFN-gamma secretion, Camrelizumab induces IFN-gamma production at an EC50 of 0.38 nM.[2]
In vivo	Camrelizumab (3 mg/kg) administered in combination with apatinib (200 and 100 mg/kg) demonstrated tumor inhibition rates of 63.1% and 87.3%, respectively, in human PD-1 transgenic mice.[1]

Synonyms	SHR-1210
Molecular Weight	N/A
CAS No.	1798286-48-2

Storage

store at low temperature

store at -20°C

References and Literature

1. Kuimin Mei, et al. Camrelizumab in combination with apatinib in second-line or above therapy for advanced primary liver cancer: cohort A report in a multicenter phase Ib/II trial. J Immunother Cancer. 2021 Mar;9(3):e002191. 2. Lickliter JD, et al. A First-in-Human Dose Finding Study of Camrelizumab in Patients with Advanced or Metastatic Cancer in Australia. Drug Des Devel Ther. 2020;14:1177-1189. 3. Caicun Zho, et al. Camrelizumab plus carboplatin and pemetrexed versus chemotherapy alone in chemotherapy-naive patients with advanced non-squamous non-small-cell lung cancer (CameL): a randomised, open-label, multicentre, phase 3 trial. Lancet Respir Med. 2021 Mar;9(3):305-314.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Camrelizumab 1798286-48-2 SHR-1210 SHR 1210 SHR1210 inhibitor inhibit

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