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Camrelizumab
😃Good
Catalog No. T37535Cas No. 1798286-48-2
Alias SHR-1210, Camrelizumab（anti-PD-1）
Camrelizumab (SHR-1210) is a human IgG4-κ monoclonal antibody with high affinity directed against PD-1, binding PD-1 with an affinity of up to 3 nM and inhibiting PD-1/PD-L1 with an IC50 of 0.70 nM. Camrelizumab exhibits anti-tumor activity and is well tolerated in cancers, including NSC-LC, ESCC, Hodgkin's lymphoma, and advanced HCC.
Camrelizumab
😃Good
Purity: 98.6%
Catalog No. T37535Alias SHR-1210, Camrelizumab（anti-PD-1）Cas No. 1798286-48-2
Camrelizumab (SHR-1210) is a human IgG4-κ monoclonal antibody with high affinity directed against PD-1, binding PD-1 with an affinity of up to 3 nM and inhibiting PD-1/PD-L1 with an IC50 of 0.70 nM. Camrelizumab exhibits anti-tumor activity and is well tolerated in cancers, including NSC-LC, ESCC, Hodgkin's lymphoma, and advanced HCC.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $163 | Backorder | |
| 5 mg | $575 | In Stock | |
| 10 mg | $823 | Backorder | |
| 25 mg | $1,220 | Backorder |
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Concentration:42.9 mg/mL
Purity:98.6%
Contact us for more batch information
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Product Introduction
Bioactivity
Chemical Properties
| Description | Camrelizumab (SHR-1210) is a human IgG4-κ monoclonal antibody with high affinity directed against PD-1, binding PD-1 with an affinity of up to 3 nM and inhibiting PD-1/PD-L1 with an IC50 of 0.70 nM. Camrelizumab exhibits anti-tumor activity and is well tolerated in cancers, including NSC-LC, ESCC, Hodgkin's lymphoma, and advanced HCC. |
| Targets&IC50 | PD-1/PD-L1:0.70 nM (IC50) |
| In vitro | In a T cell proliferation assay using tuberculin treated peripheral blood mononuclear cells, Camrelizumab induces a T cell proliferation at an EC50 of 0.11 nM. In a similar assay measuring IFN-gamma secretion, Camrelizumab induces IFN-gamma production at an EC50 of 0.38 nM.[2] |
| In vivo | Camrelizumab (3 mg/kg) administered in combination with apatinib (200 and 100 mg/kg) demonstrated tumor inhibition rates of 63.1% and 87.3%, respectively, in human PD-1 transgenic mice.[1] |
| Alias | SHR-1210, Camrelizumab（anti-PD-1） |
| Molecular Weight | 143.7 kDa |
| Cas No. | 1798286-48-2 |
Storage & Solubility Information
| Storage | store at low temperature | store at -20°C | Shipping with blue ice. |
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
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