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ACTH (1-17) acetate

Catalog No. TP1011L

ACTH (1-17) acetate is a potent agonist at the human melanocortin 1 (MC1) receptor with high affinity(Ki = 0.21 nM).

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

ACTH (1-17) acetate, CAS N/A

Pack Size	Availability	Price/USD
1 mg	In stock	$ 122.00
5 mg	In stock	$ 411.00
10 mg	In stock	$ 587.00
25 mg	In stock	$ 1,057.00
50 mg	In stock	$ 1,585.00
100 mg	In stock	$ 2,377.00

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Purity: 98.53%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	ACTH (1-17) acetate is a potent agonist at the human melanocortin 1 (MC1) receptor with high affinity(Ki = 0.21 nM).
Targets&IC50	MC1R (human):0.21 nM(Ki)
In vitro	ACTH (1-17) acetate induces a slight and not significant increase in growth hormone secretion even when micromolar concentrations of the peptide are employed in rat pituitary cultures[1]. ACTH (1-17) acetate showed an affinity for alpha-MSH with Ki of 0.13±0.005 nM[1].
In vivo	When nocturnal animals became active, inhibition of DNA markers was noted when ACTH (1-17) acetate was administered 2 hours after the start of the daily dark span. When administered during this circadian phase, particularly larger doses were associated with a 24-hour lasting inhibition of DNA markers. When the same dose was injected 4 hours earlier, the inhibitory effect was much shorter [2].

Molecular Weight	2153.47
Formula	C97H149N29O25S

Storage

store at low temperature,keep away from moisture

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Ceda GP, et al. The effects of ACTH (1-17) on GH secretion in vitro. Horm Metab Res. 1987 Aug;19(8):361-3. 2. Walker WV, et al. Effect of an adrenocorticotropin analogue, ACTH (1-17), on DNA synthesis in murine metaphyseal bone. Biochem Pharmacol. 1985 Apr 15;34(8):1191-6. 3. Tsatmali M et al. ACTH1-17 is a more potent agonist at the human MC1 receptor than alpha-MSH. Cell Mol Biol (Noisy-le-grand). 1999 Nov;45(7):1029-34.

Related compound libraries

This product is contained In the following compound libraries：

Peptide Compound Library

Related Products

Related compounds with same targets

Neuropeptide EI, rat acetate Beta-MSH (1-22) (human) acetate PG 106 acetate N,N′-Diferuloylputrescine a-MSH, amide Acetate(581-05-5 free base) Bremelanotide Acetate Bivamelagon hydrochloride Setmelanotide

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

ACTH (1-17) acetate GPCR/G Protein Neuroscience Melanocortin Receptor ACTH ACTH (117) acetate ACTH (1 17) acetate ACTH Acetate inhibitor inhibit

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.