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AGN 194310

Name: AGN 194310
Brand: TargetMol
SKU: T14143
Price: 42 USD
Availability: InStock
Rating: 4.5 (1 reviews)

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Catalog No. T14143Cas No. 229961-45-9

Alias VTP-194310

AGN 194310 (VTP-194310) is a pan-antagonist for retinoic acid receptors (RARs), with Kd values of 3 nM, 2 nM, and 5 nM for RARα, RARβ, and RARγ, respectively[1][2].

AGN 194310

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Catalog No. T14143Alias VTP-194310Cas No. 229961-45-9

AGN 194310 (VTP-194310) is a pan-antagonist for retinoic acid receptors (RARs), with Kd values of 3 nM, 2 nM, and 5 nM for RARα, RARβ, and RARγ, respectively[1][2].

Pack Size	Price	Availability
5 mg	$596	8-10 weeks
25 mg	$1,710	8-10 weeks
50 mg	$2,230	8-10 weeks
100 mg	$3,390	8-10 weeks

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Product Introduction

Bioactivity

Description	AGN 194310 (VTP-194310) is a pan-antagonist for retinoic acid receptors (RARs), with Kd values of 3 nM, 2 nM, and 5 nM for RARα, RARβ, and RARγ, respectively[1][2].
Targets&IC50	RARα:3 nM （kd）, RARβ:2 nM （kd）, RARγ:5 nM （kd）
In vitro	AGN194310 effectively inhibits colony formation in LNCaP, PC3, and DU-145 cells with IC50 values of 16 nM, 18 nM, and 34 nM, respectively[2]. At concentrations of 50 nM and 100 nM, both alone and combined with TTNPB, AGN194310 inhibits colony formation in these cell lines[2]. Additionally, treatment with AGN194310 (1 μM for 72 hours) results in 80% apoptosis in LNCaP cells[2].
In vivo	AGN 194310 (0.5 mg/kg/day; oral gavage; every day; for 10 days; female C57Bl/6J mice) treatment significantly increases granulocyte numbers across hematopoietic compartments and the frequency of granulocyte-progenitor cells in bone marrow[3].
Alias	VTP-194310

Chemical Properties

Molecular Weight	424.55
Formula	C₂₈H₂₄O₂S
Cas No.	229961-45-9
Relative Density.	1.26 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

DMSO: 50 mg/mL (117.77 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.3554 mL	11.7772 mL	23.5544 mL	117.7718 mL
5 mM	0.4711 mL	2.3554 mL	4.7109 mL	23.5544 mL
10 mM	0.2355 mL	1.1777 mL	2.3554 mL	11.7772 mL
20 mM	0.1178 mL	0.5889 mL	1.1777 mL	5.8886 mL
50 mM	0.0471 mL	0.2355 mL	0.4711 mL	2.3554 mL
100 mM	0.0236 mL	0.1178 mL	0.2355 mL	1.1777 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

Dose Conversion

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc