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Adapalene (CD271) is a dual RAR and RXR agonist, utilized in the treatment of skin conditions.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
50 mg | $42 | In Stock | |
100 mg | $66 | In Stock | |
200 mg | $97 | In Stock | |
500 mg | $189 | In Stock |
Description | Adapalene (CD271) is a dual RAR and RXR agonist, utilized in the treatment of skin conditions. |
Targets&IC50 | RARβ:2.3 nM (AC50), RARγ:9.3 nM (AC50), RARα:22 nM (AC50) |
In vitro | In rhino mice, Adapalene reduces the quantity of comedonal melanin in the epidermis and increases epidermal thickness. Within both normal skin and acne explants, Adapalene decreases the expression of TLR-2 (TLR-2) and IL-10 (IL-10). By upregulating CD1d expression and downregulating the IL-10 expression in keratinocytes, Adapalene modulates the epidermal immune system. This action enhances the interaction between dendritic cells and T lymphocytes, augmenting antimicrobial activity against Propionibacterium acnes. |
In vivo | In colorectal cancer cell lines CC-531, HT-29, and LOVO, as well as in human foreskin fibroblasts, Adapalene induces caspase-3 activity in tumor cells, inhibits DNA synthesis in a time- and dose-dependent manner, and triggers apoptosis. |
Alias | CD271 |
Molecular Weight | 412.52 |
Formula | C28H28O3 |
Cas No. | 106685-40-9 |
Smiles | COC1=CC=C(C=C1C12CC3CC(CC(C3)C1)C2)C1=CC2=CC=C(C=C2C=C1)C(O)=O |
Relative Density. | 1.233 g/cm3 |
Storage | keep away from direct sunlight,store at low temperature,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
Solubility Information | DMSO: 1 mg/ml, Sonication is recommended. |
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