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Adapalene
Catalog No. T1093Cas No. 106685-40-9
Alias CD271
Adapalene (CD271) is a dual RAR and RXR agonist, utilized in the treatment of skin conditions.
Adapalene
Catalog No. T1093Alias CD271Cas No. 106685-40-9
Adapalene (CD271) is a dual RAR and RXR agonist, utilized in the treatment of skin conditions.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 50 mg | $42 | In Stock | |
| 100 mg | $66 | In Stock | |
| 200 mg | $97 | In Stock | |
| 500 mg | $189 | In Stock |
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Purity:99.76%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | Adapalene (CD271) is a dual RAR and RXR agonist, utilized in the treatment of skin conditions. |
| Targets&IC50 | RARβ:2.3 nM (AC50), RARγ:9.3 nM (AC50), RARα:22 nM (AC50) |
| In vitro | In rhino mice, Adapalene reduces the quantity of comedonal melanin in the epidermis and increases epidermal thickness. Within both normal skin and acne explants, Adapalene decreases the expression of TLR-2 (TLR-2) and IL-10 (IL-10). By upregulating CD1d expression and downregulating the IL-10 expression in keratinocytes, Adapalene modulates the epidermal immune system. This action enhances the interaction between dendritic cells and T lymphocytes, augmenting antimicrobial activity against Propionibacterium acnes. |
| In vivo | In colorectal cancer cell lines CC-531, HT-29, and LOVO, as well as in human foreskin fibroblasts, Adapalene induces caspase-3 activity in tumor cells, inhibits DNA synthesis in a time- and dose-dependent manner, and triggers apoptosis. |
| Alias | CD271 |
| Molecular Weight | 412.52 |
| Formula | C28H28O3 |
| Cas No. | 106685-40-9 |
Storage & Solubility Information
| Storage | keep away from direct sunlight,store at low temperature,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | DMSO: 1 mg/ml, Sonication is recommended.  |
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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