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AM-1638
😃Good
Catalog No. T14200Cas No. 1142214-62-7
AM-1638 is a full agonist of GPR40/FFA1 (EC50: 0.16 μM).
AM-1638
😃Good
Catalog No. T14200Cas No. 1142214-62-7
AM-1638 is a full agonist of GPR40/FFA1 (EC50: 0.16 μM).
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 25 mg | 848 € | 8-10 weeks | |
| 50 mg | 1.102 € | 8-10 weeks | |
| 100 mg | 1.653 € | 8-10 weeks |
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Product Introduction
Bioactivity
Chemical Properties
| Description | AM-1638 is a full agonist of GPR40/FFA1 (EC50: 0.16 μM). |
| Targets&IC50 | FFA1/GPR40:0.16 μM |
| In vivo | AM-1638 demonstrates moderate cross-species plasma clearance and distribution volume, leading to plasma half-lives conducive to the assessment of its antidiabetic effects in mice, rats, and cynomolgus monkeys. It shows antidiabetic activity in BDF/DIO mice[1]. Furthermore, the oral administration of the full agonist AM-1638 reveals superb oral bioavailability, exceeding 100% in mice, and achieving 72% and 71% in rats and cynomolgus monkeys, respectively. |
| Molecular Weight | 514.63 |
| Formula | C33H35FO4 |
| Cas No. | 1142214-62-7 |
| Relative Density. | 1.193 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 250 mg/mL (485.79 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
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DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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