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AM-1638

Catalog No. T14200Cas No. 1142214-62-7

AM-1638 is a full agonist of GPR40/FFA1 (EC50: 0.16 μM).

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Pack Size	Price	Availability
25 mg	$893	8-10 weeks
50 mg	$1,160	8-10 weeks
100 mg	$1,740	8-10 weeks

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Product Introduction

Bioactivity

Description

AM-1638 is a full agonist of GPR40/FFA1 (EC50: 0.16 μM).

In vivo

AM-1638 demonstrates moderate cross-species plasma clearance and distribution volume, leading to plasma half-lives conducive to the assessment of its antidiabetic effects in mice, rats, and cynomolgus monkeys. It shows antidiabetic activity in BDF/DIO mice[1]. Furthermore, the oral administration of the full agonist AM-1638 reveals superb oral bioavailability, exceeding 100% in mice, and achieving 72% and 71% in rats and cynomolgus monkeys, respectively.

Chemical Properties

Molecular Weight	514.63
Formula	C33H35FO4
Cas No.	1142214-62-7

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 250 mg/mL (485.79 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.9431 mL	9.7157 mL	19.4314 mL	97.1572 mL
5 mM	0.3886 mL	1.9431 mL	3.8863 mL	19.4314 mL
10 mM	0.1943 mL	0.9716 mL	1.9431 mL	9.7157 mL
20 mM	0.0972 mL	0.4858 mL	0.9716 mL	4.8579 mL
50 mM	0.0389 mL	0.1943 mL	0.3886 mL	1.9431 mL
100 mM	0.0194 mL	0.0972 mL	0.1943 mL	0.9716 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

Dose Conversion

You can also refer to dose conversion for different animals. More

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc