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AM-1638
😃Good
Catalog No. T14200Cas No. 1142214-62-7
Alias AM1638
AM-1638 is an orally active GPR40/FFA1 agonist, useful for studying type II diabetes.
AM-1638
😃Good
Catalog No. T14200Alias AM1638Cas No. 1142214-62-7
AM-1638 is an orally active GPR40/FFA1 agonist, useful for studying type II diabetes.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 25 mg | $893 | 8-10 weeks | |
| 50 mg | $1,160 | 8-10 weeks | |
| 100 mg | $1,740 | 8-10 weeks |
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Product Introduction
Bioactivity
Chemical Properties
| Description | AM-1638 is an orally active GPR40/FFA1 agonist, useful for studying type II diabetes. |
| Targets&IC50 | FFA1/GPR40:0.16 μM |
| In vivo | Methods: AM-1638 (1 mg/kg, IV) and (5 mg/kg, oral) were administered to mice; AM-1638 (0.5 mg/kg, IV) and (2 mg/kg, oral) were administered to rats; and AM-1638 (0.5 mg/kg, IV) and (2 mg/kg, oral) were administered to cynomolgus monkeys for pharmacokinetic studies. Results: Oral administration of AM-1638 showed excellent oral bioavailability (mice, >100%; rats, 72%; cynomolgus monkeys, 71%); and showed antidiabetic activity in BDF/DIO mice.[1] |
| Alias | AM1638 |
| Molecular Weight | 514.63 |
| Formula | C33H35FO4 |
| Cas No. | 1142214-62-7 |
| Smiles | FC=1C(C2=C(C=C(COC3=CC([C@@H](CC(O)=O)[C@@H]4CC4)=CC=C3)C=C2)C=5C(C)(C)CCC5)=CC(OC)=CC1 |
| Relative Density. | 1.193 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 80 mg/mL (155.45 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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