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ANGIOTENSIN IV TFA(12676-15-2(free base))
Catalog No. T7743
ANGIOTENSIN IV TFA is a less effective agonist at the angiotensin AT1 receptor.
ANGIOTENSIN IV TFA(12676-15-2(free base))
Catalog No. T7743
ANGIOTENSIN IV TFA is a less effective agonist at the angiotensin AT1 receptor.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 2 mg | $36 | In Stock | |
| 5 mg | $51 | In Stock | |
| 10 mg | $88 | In Stock | |
| 25 mg | $171 | In Stock | |
| 50 mg | $256 | In Stock | |
| 100 mg | $379 | In Stock | |
| 200 mg | $539 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $107 | In Stock |
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CitedSelect Batch
Purity:≥98%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | ANGIOTENSIN IV TFA is a less effective agonist at the angiotensin AT1 receptor. |
| In vivo | Rats with CCH exhibited higher levels of Aβ42, p-tau and pro-inflammatory cytokines in the brain when compared with controls. Infusion of Ang IV significantly reduced the expression of pro-inflammatory cytokines in the brains of rats with CCH. Meanwhile, the reduction of pro-inflammatory cytokines levels caused by Ang IV was reversed by divalinal-Ang IV. During the treatment, the SBP in rats was not significantly altered[1] |
| Animal Research | Eight weeks after bilateral CCA ligation surgery, rats were anaesthetized with 10% chloral hydrate and placed in a stereotactic frame. The scalp was reflected under sterile surgical conditions. A brain-infusion cannula coupled via vinyl tubing to an osmotic pump was implanted into the third cerebral ventricle by surgeons who were blinded to the experimental groups. Osmotic pumps were placed subcutaneously between the scapulae and used to infuse two doses of Ang IV (20 nM, 0.15 μl/h and 100 nM, 0.15 μl/h), divalinal-Ang IV (500 nM, 0.15 μl/h) or aCSF (0.15 μl/h) into the third cerebral ventricle, lasting for six weeks. Following this surgery, the wounds were carefully closed with sutures[1] |
| Molecular Weight | 888.92 |
| Formula | C42H55F3N8O10 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||
| Solubility Information | DMSO: 25 mg/mL (28.12 mM)  | |||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||
DMSO
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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