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Anti-inflammatory agent 52

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Catalog No. T79598

Anti-inflammatory agent 52 (compound 7j) is an orally active, selective COX-2 inhibitor that induces G2/M phase arrest and exhibits anti-HT29 transfer activity. It demonstrates moderate anti-inflammatory efficacy and a notable safety profile, and uniquely inhibits tumor growth in mouse models, indicative of its anticancer properties [1].

Anti-inflammatory agent 52

Anti-inflammatory agent 52

😃Good
Catalog No. T79598
Anti-inflammatory agent 52 (compound 7j) is an orally active, selective COX-2 inhibitor that induces G2/M phase arrest and exhibits anti-HT29 transfer activity. It demonstrates moderate anti-inflammatory efficacy and a notable safety profile, and uniquely inhibits tumor growth in mouse models, indicative of its anticancer properties [1].
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Product Introduction

Bioactivity
Description
Anti-inflammatory agent 52 (compound 7j) is an orally active, selective COX-2 inhibitor that induces G2/M phase arrest and exhibits anti-HT29 transfer activity. It demonstrates moderate anti-inflammatory efficacy and a notable safety profile, and uniquely inhibits tumor growth in mouse models, indicative of its anticancer properties [1].
In vitro
Anti-inflammatory agent 52 (compound 7j) at 0.25 μM for 24 hours inhibits colony formation in HT29 cells and induces G2/M phase cell cycle arrest [1].
In vivo
Anti-inflammatory agent 52, also known as compound 7j, at a dosage of 50 mg/kg administered orally every other day for two weeks, was found to reduce tumor volume and weight in mice with Ehrlich solid carcinoma [1].
Chemical Properties
Molecular Weight452.95
FormulaC24H21ClN2O3S
Storage & Solubility Information
StorageShipping with blue ice.

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TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
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