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Anti-inflammatory agent 52

Catalog No. T79598

Anti-inflammatory agent 52 (compound 7j) is an orally active, selective COX-2 inhibitor with the capability to induce G2/M phase arrest and exhibit anti-HT29 transfer activity. It demonstrates moderate anti-inflammatory efficacy and a notable safety profile. Additionally, this compound possesses the uncommon ability to inhibit tumor growth in mouse models, indicative of its anticancer properties [1].

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Product Introduction

Bioactivity

Description	Anti-inflammatory agent 52 (compound 7j) is an orally active, selective COX-2 inhibitor with the capability to induce G2/M phase arrest and exhibit anti-HT29 transfer activity. It demonstrates moderate anti-inflammatory efficacy and a notable safety profile. Additionally, this compound possesses the uncommon ability to inhibit tumor growth in mouse models, indicative of its anticancer properties [1].
In vitro	Anti-inflammatory agent 52 (compound 7j) at a concentration of 0.25 μM over 24 hours inhibits colony formation in HT29 cells and induces cell cycle arrest at the G2/M phase [1].
In vivo	Anti-inflammatory agent 52, also known as compound 7j, at a dosage of 50 mg/kg administered orally every other day for two weeks, was found to reduce tumor volume and weight in mice with Ehrlich solid carcinoma [1].

Chemical Properties

Molecular Weight	452.95
Formula	C24H21ClN2O3S
Cas No.

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

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A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

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Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

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Anti-inflammatory agent 52

Anti-inflammatory agent 52

Inhibitors Related to "Anti-inflammatory agent 52"

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