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Anti-neuroinflammation agent 1
Anti-neuroinflammation agent 1
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Anti-neuroinflammation agent 1
Catalog No. T79590
Anti-neuroinflammation Agent 1 effectively modulates BV2 microglia cell polarization, shifting from an M1 to an M2 phenotype [1].
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose. | Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 5 mg | Inquiry | Backorder | |
| 50 mg | Inquiry | Backorder |
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CitedProduct Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | Anti-neuroinflammation Agent 1 effectively modulates BV2 microglia cell polarization, shifting from an M1 to an M2 phenotype [1]. |
| In vitro | Anti-neuroinflammation agent 1 (BMP 29) exhibited enhanced anti-neuroinflammatory activity without toxicity to BV2 microglial cells. In LPS-stimulated BV2 microglia, it significantly reduced M1 phenotype microglia, increased M2 phenotype, decreased pro-inflammatory cytokines (IL-18, IL-1β, TNF-α), increased anti-inflammatory cytokine (IL-10), inhibited NLRP3 inflammasome formation, and downregulated the M2 isoform of pyruvate kinase [1]. |
| In vivo | In mice, Anti-neuroinflammation Agent 1 (BMP 29) mitigates cuprizone-induced inflammation and demyelination by reducing the expression of inducible nitric oxide synthase, while simultaneously increasing the expression of CD206 [1]. |
| Molecular Weight | 523.86 |
| Formula | C22H20ClF6N3O3 |
| Cas No. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
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