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Anti-neuroinflammation agent 1
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Catalog No. T79590
Anti-neuroinflammation Agent 1 effectively modulates BV2 microglia cell polarization, shifting from an M1 to an M2 phenotype [1].
Anti-neuroinflammation agent 1
Anti-neuroinflammation agent 1
😃Good
Catalog No. T79590
Anti-neuroinflammation Agent 1 effectively modulates BV2 microglia cell polarization, shifting from an M1 to an M2 phenotype [1].
| Pack Size | Price | Availability | Quantity |
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| 5 mg | Inquiry | Backorder | |
| 50 mg | Inquiry | Backorder |
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Product Introduction
Bioactivity
Chemical Properties
| Description | Anti-neuroinflammation Agent 1 effectively modulates BV2 microglia cell polarization, shifting from an M1 to an M2 phenotype [1]. |
| In vitro | Anti-neuroinflammation agent 1 (BMP 29) exhibited enhanced anti-neuroinflammatory activity without toxicity to BV2 microglial cells. In LPS-stimulated BV2 microglia, it significantly reduced M1 phenotype microglia, increased M2 phenotype, decreased pro-inflammatory cytokines (IL-18, IL-1β, TNF-α), increased anti-inflammatory cytokine (IL-10), inhibited NLRP3 inflammasome formation, and downregulated the M2 isoform of pyruvate kinase [1]. |
| In vivo | In mice, Anti-neuroinflammation Agent 1 (BMP 29) mitigates cuprizone-induced inflammation and demyelination by reducing the expression of inducible nitric oxide synthase, while simultaneously increasing the expression of CD206 [1]. |
| Molecular Weight | 523.86 |
| Formula | C22H20ClF6N3O3 |
Storage & Solubility Information
| Storage | Shipping with blue ice. |
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DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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