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JC2-11 is an inhibitory compound for inflammation.JC2-11 inhibits the recruitment domain-containing proteins NLRC 4, atypical in melanoma 2 (AIM 2) and atypical (NC) inflammatory vesicles by disrupting reactive oxygen species (ROS) production and caspase-1 activity.JC2-11 reduces caspase-1 (p20) secretion, gasdermin D (GSDMD) cleavage, IL-1β and lactate dehydrogenase (LDH) activity in inflammatory vesicles. JC2-11 reduced caspase-1 (p20) secretion, gasdermin D (GSDMD) cleavage, IL-1β and lactate dehydrogenase (LDH) release from inflammatory vesicles.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $38 | In Stock | |
5 mg | $89 | In Stock | |
10 mg | $147 | In Stock | |
25 mg | $292 | In Stock | |
50 mg | $488 | In Stock | |
100 mg | $712 | In Stock | |
500 mg | $1,480 | In Stock | |
1 mL x 10 mM (in DMSO) | $98 | In Stock |
Description | JC2-11 is an inhibitory compound for inflammation.JC2-11 inhibits the recruitment domain-containing proteins NLRC 4, atypical in melanoma 2 (AIM 2) and atypical (NC) inflammatory vesicles by disrupting reactive oxygen species (ROS) production and caspase-1 activity.JC2-11 reduces caspase-1 (p20) secretion, gasdermin D (GSDMD) cleavage, IL-1β and lactate dehydrogenase (LDH) activity in inflammatory vesicles. JC2-11 reduced caspase-1 (p20) secretion, gasdermin D (GSDMD) cleavage, IL-1β and lactate dehydrogenase (LDH) release from inflammatory vesicles. |
In vivo | JC2-11 (250 μg/mouse; i.p.; single dose) significantly inhibited the release of caspase-1 (p20) and IL-1β from the non-canonical (NC) inflammasome in the C57BL/6 mouse model, attenuated NC inflammasome activation.[1] |
Molecular Weight | 302.3 |
Formula | C17H15FO4 |
Cas No. | 937820-89-8 |
Smiles | C(/C=C/C1=CC(OC)=C(O)C=C1)(=O)C2=CC(F)=C(OC)C=C2 |
Relative Density. | 1.257 g/cm3 (Predicted) |
Storage | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
Solubility Information | DMSO: 90.0 mg/mL (297.7 mM) | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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