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JC2-11

Catalog No. T77579Cas No. 937820-89-8

JC2-11 is an inhibitory compound for inflammation.JC2-11 inhibits the recruitment domain-containing proteins NLRC 4, atypical in melanoma 2 (AIM 2) and atypical (NC) inflammatory vesicles by disrupting reactive oxygen species (ROS) production and caspase-1 activity.JC2-11 reduces caspase-1 (p20) secretion, gasdermin D (GSDMD) cleavage, IL-1β and lactate dehydrogenase (LDH) activity in inflammatory vesicles. JC2-11 reduced caspase-1 (p20) secretion, gasdermin D (GSDMD) cleavage, IL-1β and lactate dehydrogenase (LDH) release from inflammatory vesicles.

JC2-11

JC2-11

Purity: 98.6%
Catalog No. T77579Cas No. 937820-89-8
JC2-11 is an inhibitory compound for inflammation.JC2-11 inhibits the recruitment domain-containing proteins NLRC 4, atypical in melanoma 2 (AIM 2) and atypical (NC) inflammatory vesicles by disrupting reactive oxygen species (ROS) production and caspase-1 activity.JC2-11 reduces caspase-1 (p20) secretion, gasdermin D (GSDMD) cleavage, IL-1β and lactate dehydrogenase (LDH) activity in inflammatory vesicles. JC2-11 reduced caspase-1 (p20) secretion, gasdermin D (GSDMD) cleavage, IL-1β and lactate dehydrogenase (LDH) release from inflammatory vesicles.
Pack SizePriceAvailabilityQuantity
1 mg$38In Stock
5 mg$89In Stock
10 mg$147In Stock
25 mg$292In Stock
50 mg$488In Stock
100 mg$712In Stock
500 mg$1,480In Stock
1 mL x 10 mM (in DMSO)$98In Stock
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Purity:98.6%
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Product Introduction

Bioactivity
Description
JC2-11 is an inhibitory compound for inflammation.JC2-11 inhibits the recruitment domain-containing proteins NLRC 4, atypical in melanoma 2 (AIM 2) and atypical (NC) inflammatory vesicles by disrupting reactive oxygen species (ROS) production and caspase-1 activity.JC2-11 reduces caspase-1 (p20) secretion, gasdermin D (GSDMD) cleavage, IL-1β and lactate dehydrogenase (LDH) activity in inflammatory vesicles. JC2-11 reduced caspase-1 (p20) secretion, gasdermin D (GSDMD) cleavage, IL-1β and lactate dehydrogenase (LDH) release from inflammatory vesicles.
In vivo
JC2-11 (250 μg/mouse; i.p.; single dose) significantly inhibited the release of caspase-1 (p20) and IL-1β from the non-canonical (NC) inflammasome in the C57BL/6 mouse model, attenuated NC inflammasome activation.[1]
Chemical Properties
Molecular Weight302.3
FormulaC17H15FO4
Cas No.937820-89-8
Storage & Solubility Information
StorageShipping with blue ice.
Solubility Information
DMSO: 90.0 mg/mL (297.7 mM)
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM3.3080 mL16.5399 mL33.0797 mL165.3986 mL
5 mM0.6616 mL3.3080 mL6.6159 mL33.0797 mL
10 mM0.3308 mL1.6540 mL3.3080 mL16.5399 mL
20 mM0.1654 mL0.8270 mL1.6540 mL8.2699 mL
50 mM0.0662 mL0.3308 mL0.6616 mL3.3080 mL
100 mM0.0331 mL0.1654 mL0.3308 mL1.6540 mL

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