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Pack Size | Price | Availability | Quantity |
---|---|---|---|
5 mg | $347 | 6-8 weeks | |
25 mg | $1,140 | 6-8 weeks | |
50 mg | $1,490 | 6-8 weeks | |
100 mg | $1,990 | 6-8 weeks | |
1 mL x 10 mM (in DMSO) | $375 | 6-8 weeks |
Description | Asivatrep is an effective and selective transient receptor potential vanilloid type I antagonist. |
In vitro | Asivatrep displays efficacies against diverse disease models including visceral pain, inflammatory bowel disease, and inflammatory pain. Asivatrep could prevent barrier damages, accelerate skin barrier recovery, and inhibit pruritus, displaying a potential for the treatment of atopic dermatitis. It could inhibit serum IgE increase, epidermal infiltration of inflammatory cells, and mast cell degranulation associated with atopic dermatitis[1][2]. |
In vivo | Asivatrep displays a plasma half-life of 2.1 h in rats while it is extended slightly to 3.8 h in minipigs. Asivatrep could inhibit capsaicin-evoked calcium influx in keratinocytes at sub-micromolar concentrations. This potent TRPV1 antagonistic activity in keratinocytes is manifested in vivo as the blockade of capsaicin-induced blood perfusion increases, and the accelerated barrier recovery from tape-stripping-induced barrier damages in hairless mice. Oral bioavailability at 10 mg/kg dose is determined to be 52.7% and 64.2% in rats and minipigs, respectively showing that Asivatrep is relatively well-absorbed through oral route[1][3]. |
Alias | PAC-14028 |
Molecular Weight | 491.47 |
Formula | C21H22F5N3O3S |
Cas No. | 1005168-10-4 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
Solubility Information | DMSO: 50 mg/mL (101.74 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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