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ATR-IN-23
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Catalog No. T78959Cas No. 2923800-62-6
ATR-IN-23 (Compound 34), a potent and selective ATR inhibitor, exhibits an IC50 of 1.5 nM, has demonstrated antiproliferative effects on LoVo cells, and induces synthetic lethality in HT-29 cells, suggesting its utility in researching DNA damage response (DDR)-deficient cancers [1].
ATR-IN-23
😃Good
Catalog No. T78959Cas No. 2923800-62-6
ATR-IN-23 (Compound 34), a potent and selective ATR inhibitor, exhibits an IC50 of 1.5 nM, has demonstrated antiproliferative effects on LoVo cells, and induces synthetic lethality in HT-29 cells, suggesting its utility in researching DNA damage response (DDR)-deficient cancers [1].
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 25 mg | $1,520 | 6-8 weeks | |
| 50 mg | $1,980 | 6-8 weeks | |
| 100 mg | $2,500 | 6-8 weeks |
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Product Introduction
Bioactivity
Chemical Properties
| Description | ATR-IN-23 (Compound 34), a potent and selective ATR inhibitor, exhibits an IC50 of 1.5 nM, has demonstrated antiproliferative effects on LoVo cells, and induces synthetic lethality in HT-29 cells, suggesting its utility in researching DNA damage response (DDR)-deficient cancers [1]. |
| In vitro | ATR-IN-23 exhibits significant inhibition of ATR with an IC50 value of 1.5 nM and demonstrates potent antiproliferative activity against LoVo cells, with an IC50 of 0.073 μM [1]. In HT-29 cells, ATR-IN-23 shows moderate antiproliferative efficacy with an IC50 of 0.161 μM [1]. |
| In vivo | ATR-IN-23 exhibits acute toxicity at a maximum concentration of 2000 mg/kg, demonstrating moderate safety in ICR mice [1]. When administered at 50 mg/kg either once or twice daily via oral route for 21 days, ATR-IN-23 shows moderate antitumor efficacy in BALB/c nude mice [1]. |
| Molecular Weight | 458.56 |
| Formula | C20H22N6O3S2 |
| Cas No. | 2923800-62-6 |
Storage & Solubility Information
| Storage | Shipping with blue ice. |
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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