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ATR-IN-23

Catalog No. T78959Cas No. 2923800-62-6

ATR-IN-23 (Compound 34), a potent and selective ATR inhibitor, exhibits an IC50 of 1.5 nM, has demonstrated antiproliferative effects on LoVo cells, and induces synthetic lethality in HT-29 cells, suggesting its utility in researching DNA damage response (DDR)-deficient cancers [1].

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Pack Size	Price	Availability
25 mg	$1,520	6-8 weeks
50 mg	$1,980	6-8 weeks
100 mg	$2,500	6-8 weeks

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Product Introduction

Bioactivity

Description	ATR-IN-23 (Compound 34), a potent and selective ATR inhibitor, exhibits an IC50 of 1.5 nM, has demonstrated antiproliferative effects on LoVo cells, and induces synthetic lethality in HT-29 cells, suggesting its utility in researching DNA damage response (DDR)-deficient cancers [1].
In vitro	ATR-IN-23 exhibits significant inhibition of ATR with an IC50 value of 1.5 nM and demonstrates potent antiproliferative activity against LoVo cells, with an IC50 of 0.073 μM [1]. In HT-29 cells, ATR-IN-23 shows moderate antiproliferative efficacy with an IC50 of 0.161 μM [1].
In vivo	ATR-IN-23 exhibits acute toxicity at a maximum concentration of 2000 mg/kg, demonstrating moderate safety in ICR mice [1]. When administered at 50 mg/kg either once or twice daily via oral route for 21 days, ATR-IN-23 shows moderate antitumor efficacy in BALB/c nude mice [1].

Chemical Properties

Molecular Weight	458.56
Formula	C20H22N6O3S2
Cas No.	2923800-62-6

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

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