BAY 38-7271 has strong neuroprotective properties.[1] BAY 38-7271 is selective and highly potent and cannabinoid CB1/CB2 receptor agonist. With Kis of 1.85 nM and 5.96 nM for recombinant human CB1 receptor and CB2 receptor, respectively.

CB1:1.85 nM （ki）, CB2:5.96 nM （ki）

BAY 38-7271 demonstrates minimal interactions at the micromolar range with other binding sites, including adenosine A3 receptor (IC50 = 7.5 μM), peripheral GABAA benzodiazepine receptor (IC50 = 971 nM), monoamine transporter (IC50 = 1.7 μM), and melatonin ML1 receptor (IC50 = 3.3 μM) [1].

BAY 38-7271 (Ed50 = 0.02 mg/kg; i.v. and 0.5 mg/kg; i.p.) induces a potent and dose-de-pendent reduction in core body temperature[1]. BAY 38-7271 (1-1000 ng/kg/h; i.v. infusion; for 4 hours) shows neuroprotective efficacy in the rat SDH model[1]. BAY 38-7271 has low physical dependence liability and is not essentially different from that of other cannabinoid CB1 receptor agonists[1] and it also has neuroprotective efficacy in models of transient and permanent occlusion of the middle cerebral artery and brain edema models[1].