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BAY-826

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Catalog No. T38930Cas No. 1448316-08-2

BAY-826 is a novel, potent and selective TIE-2 inhibitor that inhibits TIE-2 phosphorylation and can be used to study tumors.

BAY-826

BAY-826

🥰Excellent
Purity: 98%
Catalog No. T38930Cas No. 1448316-08-2
BAY-826 is a novel, potent and selective TIE-2 inhibitor that inhibits TIE-2 phosphorylation and can be used to study tumors.
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1 mg65 €In Stock
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Purity:98%
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Product Introduction

Bioactivity
Description
BAY-826 is a novel, potent and selective TIE-2 inhibitor that inhibits TIE-2 phosphorylation and can be used to study tumors.
Targets&IC50
Tie2:1.6 nM (Kd)
In vitro
BAY-826 is a selective and potent inhibitor of TIE-2 (dissociation constant = 1.6 nM) and binds with similar high affinity to only 4 of 456 tested kinases,namely, TIE-1,DDR1, DDR2, and Serine/threonine-protein kinase 10(LOK) (dissociation constant = 0.9, 0.4, 1.3, and 5.9 nM[1].
In vivo
A single oral dose of BAY-826 at 100, 50, or 25 mg/kg effectively inhibits ang-1-induced autophosphorylation of TIE-2 in mouse lungs[1].
Chemical Properties
Molecular Weight558.53
FormulaC26H19F5N6OS
Cas No.1448316-08-2
SmilesCc1cc(C)c(cc1NC(=O)c1cc(cc(c1)S(F)(F)(F)(F)F)C#N)-n1ccn2nc(cc12)-c1cccnc1
Storage & Solubility Information
Storagestore at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 80 mg/mL (143.23 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM1.7904 mL8.9521 mL17.9041 mL89.5207 mL
5 mM0.3581 mL1.7904 mL3.5808 mL17.9041 mL
10 mM0.1790 mL0.8952 mL1.7904 mL8.9521 mL
20 mM0.0895 mL0.4476 mL0.8952 mL4.4760 mL
50 mM0.0358 mL0.1790 mL0.3581 mL1.7904 mL
100 mM0.0179 mL0.0895 mL0.1790 mL0.8952 mL

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Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
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