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EOC317

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Purity:99.26%

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COA HPLC HNMR

EOC317

Catalog No. T4318Cas No. 939805-30-8

EOC317 (ACTB-1003) is an oral kinase inhibitor (IC50: 6/2/4 nM, for FGFR1/VEGFR2/Tie-2).

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Pack Size	Price	Availability
1 mg	$93	In Stock
2 mg	$137	In Stock
5 mg	$198	In Stock
10 mg	$347	In Stock
25 mg	$589	In Stock
50 mg	$842	In Stock
100 mg	$1,160	In Stock
1 mL x 10 mM (in DMSO)	$268	In Stock

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Product Introduction

Bioactivity

Description	EOC317 (ACTB-1003) is an oral kinase inhibitor (IC50: 6/2/4 nM, for FGFR1/VEGFR2/Tie-2).
In vitro	ACTB-1003 targets cancer mutations via FGFR inhibition FGFR1 (IC50: 6 nM), angiogenesis through inhibition of VEGFR2 (2 nM) and Tie-2 (4 nM), and induces apoptosis likely by targeting RSK (5 nM) and p70S6K (32 nM). In cell lines with FGFR genetic alterations - OPM2 human multiple myeloma and the murine leukemia Ba/F3-TEL-FGFR1, ACTB-1003 can markedly and dose-dependently inhibit tumor growth. OPM2 cells harbor the FGFR3 t (4:14) translocation, FGFR3 K650E mutation and PTEN deletion while the Ba/F3-TEL-FGFR1 cells are driven by FGFR1 over-expression.
In vivo	ACTB-1003 inhibit tumor angiogenesis evident by the inhibition of CD31 staining in tumor sections. The combination ACTB-1003 with 5-FU or paclitaxel not diminish the activity or increasing the toxicity of these chemotherapy agents in the HCT-116 colon tumor xenograft model.
Alias	ACTB-1003, ACTB1003, ACTB 1003

Chemical Properties

Molecular Weight	591.53
Formula	C27H26F5N7O3
Cas No.	939805-30-8

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 55 mg/mL (92.98 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.6905 mL	8.4527 mL	16.9053 mL	84.5266 mL
5 mM	0.3381 mL	1.6905 mL	3.3811 mL	16.9053 mL
10 mM	0.1691 mL	0.8453 mL	1.6905 mL	8.4527 mL
20 mM	0.0845 mL	0.4226 mL	0.8453 mL	4.2263 mL
50 mM	0.0338 mL	0.1691 mL	0.3381 mL	1.6905 mL

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In Vivo Formulation Calculator (Clear solution)

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DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

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Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

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