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Pack Size | Price | Availability | Quantity |
---|---|---|---|
2 mg | $79 | In Stock |
Description | CE-245677 is a potent, reversible inhibitor of Tie2 and TrkA/B kinases, with cellular IC50 values of 4.7 nM and 1 nM, respectively. |
Targets&IC50 | Tie2:4.7 nM, TrkA:1 nM, TrkB:1 nM |
In vitro | CE-245677 is a potent reversible inhibitor of Tie2 and TrkA/B kinases, with cellular IC50 values of 4.7 and 1 nM, respectively. It exhibits over 100-fold selectivity against various other angiogenic receptor tyrosine kinases, including KDR, PDGFR, and FGFR[1]. |
In vivo | In vivo rat, CE-245677 displays good oral absorption PK studies (F=80%)[1]. |
Molecular Weight | 513.38 |
Formula | C24H22Cl2N6O3 |
Cas No. | 717899-97-3 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
Solubility Information | DMSO: 125 mg/mL (243.48 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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