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CE-245677 mesylate

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Catalog No. T68286Cas No. 941588-94-9

CE-245677 is a selective, orally active Tie2 kinase inhibitor identified by Pfizer previously in development for the treatment of certain cancers. CE-245,677 is a potent reversible inhibitor of Tie2 and TrkA/B kinases with a cellular IC50 of 4.7 and 1 nM, resp., displays >100x selectivity against a number of other angiogenic receptor tyrosine kinases (e.g. KDR, PDGFR, FGFR) and gene family panels, and demonstrates good oral absorption in in vivo rat PK studies (F=80%).

CE-245677 mesylate

CE-245677 mesylate

😃Good
Catalog No. T68286Cas No. 941588-94-9
CE-245677 is a selective, orally active Tie2 kinase inhibitor identified by Pfizer previously in development for the treatment of certain cancers. CE-245,677 is a potent reversible inhibitor of Tie2 and TrkA/B kinases with a cellular IC50 of 4.7 and 1 nM, resp., displays >100x selectivity against a number of other angiogenic receptor tyrosine kinases (e.g. KDR, PDGFR, FGFR) and gene family panels, and demonstrates good oral absorption in in vivo rat PK studies (F=80%).
Pack SizePriceAvailabilityQuantity
25 mg1.444 â‚¬6-8 weeks
50 mg1.881 â‚¬6-8 weeks
100 mg2.375 â‚¬6-8 weeks
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Product Introduction

Bioactivity
Description
CE-245677 is a selective, orally active Tie2 kinase inhibitor identified by Pfizer previously in development for the treatment of certain cancers. CE-245,677 is a potent reversible inhibitor of Tie2 and TrkA/B kinases with a cellular IC50 of 4.7 and 1 nM, resp., displays >100x selectivity against a number of other angiogenic receptor tyrosine kinases (e.g. KDR, PDGFR, FGFR) and gene family panels, and demonstrates good oral absorption in in vivo rat PK studies (F=80%).
Chemical Properties
Molecular Weight609.479
FormulaC25H26Cl2N6O6S
Cas No.941588-94-9
Storage & Solubility Information
StorageShipping with blue ice.

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