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BBC0403
🥰Excellent
Catalog No. T88118Cas No. 2644662-83-7
Alias BBC 0403
BBC0403 is a selective BRD2 inhibitor that inhibits BRD2 and BRD2, suppressing NF-κB and MAPK signaling pathways. It can be used in osteoarthritis (OA) research.
BBC0403
🥰Excellent
Catalog No. T88118Alias BBC 0403Cas No. 2644662-83-7
BBC0403 is a selective BRD2 inhibitor that inhibits BRD2 and BRD2, suppressing NF-κB and MAPK signaling pathways. It can be used in osteoarthritis (OA) research.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 5 mg | $288 | In Stock | |
| 10 mg | $465 | In Stock |
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Product Introduction
Bioactivity
Chemical Properties
| Description | BBC0403 is a selective BRD2 inhibitor that inhibits BRD2 and BRD2, suppressing NF-κB and MAPK signaling pathways. It can be used in osteoarthritis (OA) research. |
| Targets&IC50 | BRD2 (BD2):7.64 μM (Kd), BRD2 (BD1):41.37 μM (Kd) |
| In vitro | BBC0403 is a selective BRD2 inhibitor with Kd values of 7.64 μM for BRD2 (BD2) and 41.37 μM for BRD2 (BD1).BBC0403 significantly inhibited the expression of catabolic factors, the production of prostaglandin E2 (PGE2) and the degradation of the extracellular matrix (ECM) after treatment with BBC0403 at 5 μM, 10 μM, and 20 μM for 12 h. BBC0403 inhibits catabolic factor expression, prostaglandin E2 (PGE2) production, and the degradation of ECM. and extracellular matrix (ECM) degradation. By blocking the NF-κB and MAPK signaling pathways, BBC0403 helps to alleviate the development of osteoarthritis (OA). [1] |
| In vivo | Weekly intra-articular injection of 5-10 μg/kg of BBC0403 for 6 weeks effectively prevented the degradation of osteoarthritic cartilage in a mouse model. [1] |
| Alias | BBC 0403 |
| Molecular Weight | 382.41 |
| Formula | C21H22N2O5 |
| Cas No. | 2644662-83-7 |
| Smiles | O=C1N=C(NC=2C=C(OC)C=C(OC)C12)C=3C=C(C(OC4COC4)=C(C3)C)C |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 20 mg/mL (52.3 mM), Sonication is recommended. | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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