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BMS-502

🥰Excellent
Catalog No. T77761Cas No. 2407854-18-4

BMS-502 is a potent dual inhibitor of diacylglycerol kinase (DGK) α and ζ that induces immune responses in human and mouse T cells and blocks intracellular checkpoint signaling in T cells. BMS-502 stimulates immune responses in a dose-dependent manner and can be used to study immune-related diseases.

BMS-502

BMS-502

🥰Excellent
Purity: 99.78%
Catalog No. T77761Cas No. 2407854-18-4
BMS-502 is a potent dual inhibitor of diacylglycerol kinase (DGK) α and ζ that induces immune responses in human and mouse T cells and blocks intracellular checkpoint signaling in T cells. BMS-502 stimulates immune responses in a dose-dependent manner and can be used to study immune-related diseases.
Pack SizePriceAvailabilityQuantity
1 mg$126 In Stock
5 mg$313 In Stock
10 mg$488 In Stock
25 mg$819 In Stock
50 mg$1,080 In Stock
100 mg$1,490 In Stock
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Purity:99.78%
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Product Introduction

Bioactivity
Description
BMS-502 is a potent dual inhibitor of diacylglycerol kinase (DGK) α and ζ that induces immune responses in human and mouse T cells and blocks intracellular checkpoint signaling in T cells. BMS-502 stimulates immune responses in a dose-dependent manner and can be used to study immune-related diseases.
Targets&IC50
DGK ζ:2.1nM, DGK α:4.6 nM
Chemical Properties
Molecular Weight516.5
FormulaC27H22F2N6O3
Cas No.2407854-18-4
SmilesN#CC1=NC2=C(N(C)C(C([N+]([O-])=O)=C2N3CCN(C(C4=CC=C(C=C4)F)C5=CC=C(C=C5)F)CC3)=O)C=C1
Relative Density.no data available
Storage & Solubility Information
Storagekeep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 80 mg/mL (154.89 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM1.9361 mL9.6805 mL19.3611 mL96.8054 mL
5 mM0.3872 mL1.9361 mL3.8722 mL19.3611 mL
10 mM0.1936 mL0.9681 mL1.9361 mL9.6805 mL
20 mM0.0968 mL0.4840 mL0.9681 mL4.8403 mL
50 mM0.0387 mL0.1936 mL0.3872 mL1.9361 mL
100 mM0.0194 mL0.0968 mL0.1936 mL0.9681 mL

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TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
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