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BTD
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Catalog No. T37763Cas No. 896684-04-1
BTD is a selective transient receptor potential classical 5 (TRPC5) activator, which activates heteromeric channel complexes formed by TRPC5 and its recent relatives TRPC1 or TRPC4, used for studying neurodegenerative diseases.
BTD
😃Good
Catalog No. T37763Cas No. 896684-04-1
BTD is a selective transient receptor potential classical 5 (TRPC5) activator, which activates heteromeric channel complexes formed by TRPC5 and its recent relatives TRPC1 or TRPC4, used for studying neurodegenerative diseases.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 2 mg | $48 | 5 days |
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Product Introduction
Bioactivity
Chemical Properties
| Description | BTD is a selective transient receptor potential classical 5 (TRPC5) activator, which activates heteromeric channel complexes formed by TRPC5 and its recent relatives TRPC1 or TRPC4, used for studying neurodegenerative diseases. |
| Targets&IC50 | TRPC5:1.4 μM (EC50) |
| In vitro | BTD can activate TRPC5 with EC50 values of 1.4 μM (fluorescence microporous Ca2+ analysis) and 1.3 μM (in whole-cell patch-clamp experiments). BTD can activate TRPM8-expressing HEK293 cells with an EC50 value of 20.6 μM. BTD can activate the heteropolymeric channel complex composed of TRPC5 and its close relatives, TRPC1 or TRPC4. [1] BTD treatment down-regulates TRPC5 expression by increasing the activity of protein kinase C, thereby down-regulating downstream pain markers (CAMKII, ERK) in the spinal cord. [2] |
| In vivo | BTD (1 and 3 mg/kg intraperitoneally injected for 14 days) improved mechanical pain in diabetic neuropathic rats, but did not improve hypothermia or neurological deficits. [2] |
| Molecular Weight | 459.6 |
| Formula | C24H33N3O4S |
| Cas No. | 896684-04-1 |
| Smiles | O=C(NCCCOC12CC3CC(CC(C3)C1)C2)CCC4=NS(=O)(=O)C5=CC=C(C=C5N4)C |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 80 mg/mL (174.06 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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