store at low temperature,keep away from moisture
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
cAC 253 acetate (TP2135 Free base) is an amylin antagonist. cAC 253 acetate inhibits 125I-adrenomedullin binding, with an IC50 of 25 nM.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 195.00 | |
5 mg | In stock | $ 447.00 | |
10 mg | In stock | $ 659.00 | |
25 mg | In stock | $ 987.00 | |
50 mg | In stock | $ 1,380.00 |
Description | cAC 253 acetate (TP2135 Free base) is an amylin antagonist. cAC 253 acetate inhibits 125I-adrenomedullin binding, with an IC50 of 25 nM. |
In vitro | cAC 253 acetate (5-20 μM) antagonizes adrenomedullin-stimulated cAMP production at micromolar concentrations[1]. cAC 253 acetate (5-10 μM) blocks increases in intracellular Ca2+, activation of protein kinase A, MAPK, Akt, cFos, and cell death, which occur upon AMY3 activation with hAmylin, Aβ1-42, or their co-application[2]. cAC 253 acetate (10 nM) blocks Aβ1-42-induced electrophysiological effects[3]. |
Synonyms | cAC 253 acetate (TP2135 Free base) |
Molecular Weight | 3069.39 |
Formula | C128H206N42O42S2 |
CAS No. | TP2135L |
store at low temperature,keep away from moisture
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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cAC 253 acetate TP2135L GPCR/G Protein Amylin Receptor cAC 253 acetate (TP2135 Free base) TP 2135 TP2135 Free base cAC 253 Acetate cAC-253 Acetate cAC253 Acetate TP2135 TP-2135 inhibitor inhibit