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Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $195 | In Stock | |
5 mg | $447 | In Stock | |
10 mg | $659 | In Stock | |
25 mg | $987 | In Stock | |
50 mg | $1,380 | In Stock |
Description | cAC 253 acetate (TP2135 Free base) is an amylin antagonist. cAC 253 acetate inhibits 125I-adrenomedullin binding, with an IC50 of 25 nM. |
In vitro | cAC 253 acetate (5-20 μM) antagonizes adrenomedullin-stimulated cAMP production at micromolar concentrations[1]. cAC 253 acetate (5-10 μM) blocks increases in intracellular Ca2+, activation of protein kinase A, MAPK, Akt, cFos, and cell death, which occur upon AMY3 activation with hAmylin, Aβ1-42, or their co-application[2]. cAC 253 acetate (10 nM) blocks Aβ1-42-induced electrophysiological effects[3]. |
Alias | cAC 253 acetate (TP2135 Free base) |
Molecular Weight | 3069.39 |
Formula | C128H206N42O42S2 |
Cas No. |
Storage | store at low temperature,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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