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Calhex 231 hydrochloride
Catalog No. T10666Cas No. 2387505-78-2
Calhex 231 hydrochloride is a CaSR inhibitor with potential for diabetic cardiomyopathy treatment; it blocks Ca2+-induced accumulation of [3H]inositol phosphate with an IC50 of 0.39 μM in HEK293 cells.
Calhex 231 hydrochloride
Catalog No. T10666Cas No. 2387505-78-2
Calhex 231 hydrochloride is a CaSR inhibitor with potential for diabetic cardiomyopathy treatment; it blocks Ca2+-induced accumulation of [3H]inositol phosphate with an IC50 of 0.39 μM in HEK293 cells.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 2 mg | $88 | 5 days | |
| 5 mg | $148 | 5 days |
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Product Introduction
Bioactivity
Chemical Properties
| Description | Calhex 231 hydrochloride is a CaSR inhibitor with potential for diabetic cardiomyopathy treatment; it blocks Ca2+-induced accumulation of [3H]inositol phosphate with an IC50 of 0.39 μM in HEK293 cells. |
| Targets&IC50 | CaSR:0.39 μM |
| In vitro | Calhex 231 could inhibit Itch (atrophin-1 interacting protein 4)-ubiquitin proteasome and TGF-β1/Smads pathways, and then depress the proliferation of cardiac fibroblasts, along with the reduction deposition of collagen, alleviate glucose-induced myocardial fibrosis. Calhex 231 treatment significantly downregulates the CaSR, α-SMA, Col-I/III, MMP2/9 expresses. Calhex231 alleviates high glucose-induced myocardial fibrosis in cardiac fibroblasts [1]. |
| In vivo | In the type 1 diabetic model (T1D) rats, Calhex 231 (4.07 mg/kg; i.p.; daily; for 12 weeks; male Wistar rats) treatment ameliorates diabetic myocardial fibrosis [1]. |
| Molecular Weight | 443.41 |
| Formula | C25H28Cl2N2O |
| Cas No. | 2387505-78-2 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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