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Gadolinium chloride
Catalog No. T22795Cas No. 10138-52-0
Gadolinium chloride is a calcium-sensing receptor (CaSR) agonist
Gadolinium chloride
Catalog No. T22795Cas No. 10138-52-0
Gadolinium chloride is a calcium-sensing receptor (CaSR) agonist
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 25 mg | $41 | In Stock | |
| 50 mg | $53 | In Stock | |
| 100 mg | $82 | In Stock | |
| 200 mg | $128 | In Stock |
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Product Introduction
Bioactivity
Chemical Properties
| Description | Gadolinium chloride is a calcium-sensing receptor (CaSR) agonist |
| In vitro | Gadolinium chloride (GdCl ) , a well-known Kupffer/foam cell inhibitor, at late stages of NPC liver disease and compared it with NPC1 genetic rescue in hepatocytes in vivo.?GdCl treatment successfully blocked the endocytic capacity of hepatic Kupffer/foam measured by India ink endocytosis, decreased the levels CD68-A marker of Kupffer cells in the liver-and normalized the transaminase levels in serum of NPC mice to a similar extent to those obtained by genetic Npc1 rescue of liver cells.?Gadolinium salts are widely used as magnetic resonance imaging (MRI) contrasts.?This study opens the possibility of targeting foam cells with gadolinium or by other means for improving NPC liver disease.?Synopsis: Gadolinium chloride can effectively rescue some parameters of liver dysfunction in NPC mice and its potential use in patients should be carefully evaluated. |
| Molecular Weight | 263.61 |
| Formula | Cl3Gd |
| Cas No. | 10138-52-0 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||
| Solubility Information | DMSO: 7.5 mg/mL (28.45 mM), Sonication is recommended.  H2O: 9.85 mg/mL | |||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||
DMSO
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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