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CD73-IN-18
Catalog No. T200672Cas No. 3037968-61-6
CD73-IN-18 (compound 35j) is an orally effecTive inhibiTor of The exTracellular 5'-nucleoTidase (CD73) enzyme. IT can be uTilized in anTicancer research.
CD73-IN-18
Catalog No. T200672Cas No. 3037968-61-6
CD73-IN-18 (compound 35j) is an orally effecTive inhibiTor of The exTracellular 5'-nucleoTidase (CD73) enzyme. IT can be uTilized in anTicancer research.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 10 mg | Inquiry | 10-14 weeks | |
| 50 mg | Inquiry | 10-14 weeks |
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PSB-12379 ditriethylamine salt
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PSB-12379 ditriethylamine salt, a nucleotide analogue, is a potent Ecto-5'-Nucleotidase (CD73) inhibitor with Kis of 9.03 nM (rat) and 2.21 nM (human).
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AB-680
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AB-680, a highly potent, reversible, and selective inhibitor of CD73 (an ectonucleotidase, Ki: 4.9 pM for hCD73) with anti-tumor activity, displays >10,000-fold selectivity over related ectonucleotidases CD39.
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MethADP
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MethADP (Adenosine 5'-(α,β-methylene)diphosphate) is a specific CD73 inhibitor that inhibits the enzyme ecto-5′-nucleotidase (ecto), which has been used in the study of neurological and cardiovascular diseases.
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CD73-IN-3
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CD73-IN-4
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Oleclumab
MEDI-9447, MEDI9447, MED I9447
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Oleclumab (MEDI9447) is a human anti-CD73 monoclonal antibody with anticancer activity that inhibits the extracellular enzyme CD73 nucleic acid exonuclease activity, inhibits the adenosine pathway, and can be used for the study of metastatic desmoplasia-resistant prostate cancer.
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CD73-IN-1
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CD73-IN-1 is a CD73 inhibitor with anticancer activity.
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Mupadolimab
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Mupadolimab (CPI-006) is a humanized FC-γR binding deficient IgG1 anti-CD73 antibody with potential anticancer activity and activation of CD73POS B cells.
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Dresbuxelimab
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Dresbuxelimab (AK-119), an IgG-κ monoclonal antibody, selectively targets CD73 and is commonly produced using a Chinese Hamster Ovary (CHO) cell expression system [1].
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CD73-IN-17
T200431
CD73-IN-17 (compound 19) is an inhibiTor of CD73 wiTh an IC50 of 0.1 μM againsT hCD73. IT is applicable in cancer research.
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CD73-IN-16
T200673
CD73-IN-16 (compound 18) acTs as an inhibiTor of hCD73, exhibiTing an IC50 value of 0.28 μM.
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Product Introduction
Bioactivity
Chemical Properties
| Description | CD73-IN-18 (compound 35j) is an orally effecTive inhibiTor of The exTracellular 5'-nucleoTidase (CD73) enzyme. IT can be uTilized in anTicancer research. |
| Molecular Weight | 375.38 |
| Formula | C20H17N5O3 |
| Cas No. | 3037968-61-6 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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