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Oleclumab
Catalog No. T76695Cas No. 1803176-05-7
Alias MEDI-9447, MEDI9447, MED I9447
Oleclumab (MEDI9447) is a human anti-CD73 monoclonal antibody with anticancer activity that inhibits the extracellular enzyme CD73 nucleic acid exonuclease activity, inhibits the adenosine pathway, and can be used for the study of metastatic desmoplasia-resistant prostate cancer.
Oleclumab
Oleclumab
Catalog No. T76695Alias MEDI-9447, MEDI9447, MED I9447Cas No. 1803176-05-7
Oleclumab (MEDI9447) is a human anti-CD73 monoclonal antibody with anticancer activity that inhibits the extracellular enzyme CD73 nucleic acid exonuclease activity, inhibits the adenosine pathway, and can be used for the study of metastatic desmoplasia-resistant prostate cancer.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $479 | In Stock | |
| 5 mg | $1,180 | In Stock | |
| 10 mg | $1,620 | In Stock | |
| 25 mg | $2,380 | In Stock |
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Dresbuxelimab
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Dresbuxelimab (AK-119), an IgG-κ monoclonal antibody, selectively targets CD73 and is commonly produced using a Chinese Hamster Ovary (CHO) cell expression system [1].
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Concentration:16.07 mg/mL
Purity:100% (SEC-HPLC)
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Product Introduction
Bioactivity
Chemical Properties
| Description | Oleclumab (MEDI9447) is a human anti-CD73 monoclonal antibody with anticancer activity that inhibits the extracellular enzyme CD73 nucleic acid exonuclease activity, inhibits the adenosine pathway, and can be used for the study of metastatic desmoplasia-resistant prostate cancer. |
| In vivo | In the Murine Balb/c syngeneic CT26 colon carcinoma tumor model, intraperitoneal administration of Oleclumab (10 mg/kg; twice per week for 2 weeks) resulted in a significant inhibition of tumor growth by at least 50% from day 7 to day 16 compared to the isotype control antibody-treated groups[2]. |
| Alias | MEDI-9447, MEDI9447, MED I9447 |
| Molecular Weight | 143.14 kDa |
| Cas No. | 1803176-05-7 |
Storage & Solubility Information
| Storage | store at low temperature | store at -80°C | Shipping with blue ice. |
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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