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AB-680

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Purity:97.98%

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COA HNMR HPLC

AB-680

Catalog No. T10216Cas No. 2105904-82-1

AB-680, a highly potent, reversible, and selective inhibitor of CD73 (an ectonucleotidase, Ki: 4.9 pM for hCD73) with anti-tumor activity, displays >10,000-fold selectivity over related ectonucleotidases CD39.

With extensive experience in compound synthesis, we can provide rapid custom synthesis services for this product according to your research needs.

Pack Size	Price	Availability
1 mg	$115	In Stock
2 mg	$163	In Stock
5 mg	$247	In Stock
10 mg	$393	In Stock
25 mg	$658	In Stock
50 mg	$937	In Stock
100 mg	$1,270	In Stock
1 mL x 10 mM (in DMSO)	$316	In Stock

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Product Introduction

Bioactivity

Description	AB-680, a highly potent, reversible, and selective inhibitor of CD73 (an ectonucleotidase, Ki: 4.9 pM for hCD73) with anti-tumor activity, displays >10,000-fold selectivity over related ectonucleotidases CD39.
Targets&IC50	CD73:4.9 pM (ki;human), CD73:43 pM (Soluble hCD73)
In vitro	AB-680 inhibits soluble hCD73 (IC50: 0.043 nM), also inhibits hCD73 in CHO cells, suppresses CD73 in human, mouse CD8+ T Cells and hPBMC, with IC50s of 0.070, 0.008, 0.66 and 0.011 nM, respectively.

Chemical Properties

Molecular Weight	580.82
Formula	C20H24ClFN4O9P2
Cas No.	2105904-82-1

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

DMSO: 180 mg/mL (309.91 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.7217 mL	8.6085 mL	17.2170 mL	86.0852 mL
5 mM	0.3443 mL	1.7217 mL	3.4434 mL	17.2170 mL
10 mM	0.1722 mL	0.8609 mL	1.7217 mL	8.6085 mL
20 mM	0.0861 mL	0.4304 mL	0.8609 mL	4.3043 mL
50 mM	0.0344 mL	0.1722 mL	0.3443 mL	1.7217 mL
100 mM	0.0172 mL	0.0861 mL	0.1722 mL	0.8609 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc