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PSB-12379 ditriethylamine salt, a nucleotide analogue, is a potent Ecto-5'-Nucleotidase (CD73) inhibitor with Kis of 9.03 nM (rat) and 2.21 nM (human).
Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $70 | In Stock | |
5 mg | $161 | In Stock | |
10 mg | $237 | In Stock | |
25 mg | $355 | In Stock | |
50 mg | $500 | In Stock | |
100 mg | $672 | In Stock | |
200 mg | $890 | In Stock | |
1 mL x 10 mM (in DMSO) | $231 | In Stock |
Description | PSB-12379 ditriethylamine salt, a nucleotide analogue, is a potent Ecto-5'-Nucleotidase (CD73) inhibitor with Kis of 9.03 nM (rat) and 2.21 nM (human). |
In vitro | Metabolism: Only a small percentage (<23%) of PSB-12379 (10g) is metabolized under the applied conditions, while >77% of the compounds are recovered unchanged after a long incubation for 8 h. PSB-12379 (10g) is somewhat less stable, and 56% are metabolized within 8 h. Hydrolytic cleavage of the glycosidic bond, which is a typical phase I reaction of nucleosides and nucleotides, was observed as the main reaction[1]. |
Molecular Weight | 717.73 |
Formula | C30H53N7O9P2 |
Smiles | O=P(CP(O)(O)=O)(O)OC[C@@H](O1)[C@@H](O)[C@@H](O)[C@@H]1N2C3=NC=NC(NCC4=CC=CC=C4)=C3N=C2.CCN(CC)CC.CCN(CC)CC |
Relative Density. | no data available |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||
Solubility Information | DMSO: 11 mg/mL (15.33 mM) ![]() | ||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||
DMSO
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