Chlorantraniliprole (Rynaxypyr) is an insecticide. Chlorantraniliprole potently and selectively activates insect ryanodine receptor, with EC50s of 40 nM and 50 nM for Drosophila melanogaster and H. virescens ryanodine receptor, and ∼300-fold more potent than that in the mouse myoblast cell line, C2C12 (EC50, 14 μM).

Chlorantraniliprole potently and selectively activates insect ryanodine receptor. Chlorantraniliprole actions by release of intracellular Ca2+ stores mediated by the ryanodine receptor. Chlorantraniliprole is ∼300-fold less potent against ryanodine receptor (RyRs) in the mouse myoblast cell line, C2C12 (EC50, 14 μM), than in insect RyRs from Drosophila melanogaster and H. virescens (EC50, 40 nM, 50 nM), and shows little selectivity at the rat cell line RyR2 (EC50, >100 μM)[1].

Chlorantraniliprole exhibits low acute toxicity in mammals, with rats demonstrating an acute oral LD50 exceeding 5000 mg/kg. Additionally, it shows minimal to no toxicity in 90-day studies, even when administered at doses up to 1500 mg/kg/day[1].