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Atumelnant
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Catalog No. T86091Cas No. 2392970-97-5
Alias CRN04894, CRN 04894
Atumelnant (CRN04894) is a selective and potent MC2R antagonist that inhibits ACTH-stimulated corticosterone secretion in a dose-dependent manner for the study of congenital adrenocortical hyperplasia (CAH) and Cushing's disease (CD).
Atumelnant
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Purity: 98.41%
Catalog No. T86091Alias CRN04894, CRN 04894Cas No. 2392970-97-5
Atumelnant (CRN04894) is a selective and potent MC2R antagonist that inhibits ACTH-stimulated corticosterone secretion in a dose-dependent manner for the study of congenital adrenocortical hyperplasia (CAH) and Cushing's disease (CD).
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 10 mg | Inquiry | 10-14 weeks | |
| 50 mg | Inquiry | 10-14 weeks |
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Purity:98.41%
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Product Introduction
Bioactivity
Chemical Properties
| Description | Atumelnant (CRN04894) is a selective and potent MC2R antagonist that inhibits ACTH-stimulated corticosterone secretion in a dose-dependent manner for the study of congenital adrenocortical hyperplasia (CAH) and Cushing's disease (CD). |
| Targets&IC50 | MC2R (rat):0.23 nM (KB), MC2R (human):0.34 nM (KB) |
| In vitro | Atumelnant is an orally potent MC2R antagonist that inhibits corticosterone secretion induced by adrenocorticotropic hormone (ACTH) stimulation in a rat model. Atumelnant has a binding constant (KB value) of 0.34 nM for human MC2R and 0.23 nM for rat MC2R. [1] |
| In vivo | In an ACTH-stimulated male rat model, single oral administration of Atumelnant at 3 mg/kg and 30 mg/kg significantly and dose-dependently reduced corticosterone secretion levels. [1] |
| Alias | CRN04894, CRN 04894 |
| Molecular Weight | 613.71 |
| Formula | C33H42F3N5O3 |
| Cas No. | 2392970-97-5 |
| Smiles | C(=O)(C1(C(F)(F)F)CCC1)N2C[C@@H](CC)N(CC2)C3=C(C(N[C@H]4C5CCN(C4)CC5)=O)N=C(C=C3)C6=C(OCC)C=CC=C6 |
Storage & Solubility Information
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 80 mg/mL (130.35 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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