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Pack Size | Price | Availability | Quantity |
---|---|---|---|
10 mg | Inquiry | 10-14 weeks | |
50 mg | Inquiry | 10-14 weeks |
Description | CRN04894 (compound 17h), an orally active MC2R antagonist, effectively inhibits adrenocorticotropic hormone (ACTH)-stimulated corticosterone secretion in a rat model[1]. It exhibits strong binding to MC2R in both human and rat, with K B values of 0.34 nM and 0.23 nM, respectively[1]. |
Targets&IC50 | MC2R:0.34 nM (Kb), rat MC2R:0.23 nM (Kb) |
In vivo | CRN04894 (compound 17h), when administered orally in a single dose of 3 mg/kg and 30 mg/kg, significantly reduced corticosterone secretion levels in a dose-dependent manner in male Sprague-Dawley rat models post-stimulation with ACTH(1-24), four hours after treatment [1]. |
Molecular Weight | 613.71 |
Formula | C33H42F3N5O3 |
Cas No. | 2392970-97-5 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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