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Crosstide TFA(171783-05-4 free base)

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Purity:99.67%

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COA LCMS HNMR

Crosstide TFA(171783-05-4 free base)

Catalog No. TP1370L

Crosstide is a peptide analog of glycogen synthase kinase α/β fusion protein sequence which is a substrate for Akt.

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Pack Size	Price	Availability
1 mg	$103	In Stock
5 mg	$402	In Stock
10 mg	$515	In Stock
25 mg	$679	In Stock
50 mg	$883	In Stock
100 mg	$1,130	In Stock
500 mg	$2,280	In Stock

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Product Introduction

Bioactivity

Description

Crosstide is a peptide analog of glycogen synthase kinase α/β fusion protein sequence which is a substrate for Akt.

In vitro

16HBE14o? cells exposed to RV39 demonstrate a crosstide kinase activity in vitro. Serine phosphorylation of crosstide is confirmed by immunoblotting, and phosphorylation is blocked by PP2 but not by PP3[1]. The wildtype GST-AKT2 shows significant phosphoryl transferase activity towards crosstide, reaching an initial velocity of 16 pmol phosphate/min/μg enzyme. The mutant GST-AKT2T/E,S/D displayed an initial velocity of 85 pmol phosphate/min/μg kinase for phosphorylation of Crosstide, corresponding to a 5-fold increase compared to the wildtype enzyme[2].

Chemical Properties

Molecular Weight	1278.25
Formula	C50H78F3N17O19
Cas No.

Storage & Solubility Information

Storage

keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

H2O: 50 mg/mL (42.95 mM)

Solution Preparation Table

H2O

	1mg	5mg	10mg	50mg
1 mM	0.7823 mL	3.9116 mL	7.8232 mL	39.1160 mL
5 mM	0.1565 mL	0.7823 mL	1.5646 mL	7.8232 mL
10 mM	0.0782 mL	0.3912 mL	0.7823 mL	3.9116 mL
20 mM	0.0391 mL	0.1956 mL	0.3912 mL	1.9558 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

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A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

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Tech Support

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Keywords

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