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Depatuxizumab

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Catalog No. T78326Cas No. 1471999-69-5
Alias ABT-806

Depatuxizumab, a brain-penetrant, humanized anti-EGFR monoclonal antibody, selectively inhibits the growth of mutant EGFRvIII and wild-type EGFR xenograft models, and is utilized for research on cancer [1].

Depatuxizumab

Depatuxizumab

😃Good
Catalog No. T78326Alias ABT-806Cas No. 1471999-69-5
Depatuxizumab, a brain-penetrant, humanized anti-EGFR monoclonal antibody, selectively inhibits the growth of mutant EGFRvIII and wild-type EGFR xenograft models, and is utilized for research on cancer [1].
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Bioactivity
Description
Depatuxizumab, a brain-penetrant, humanized anti-EGFR monoclonal antibody, selectively inhibits the growth of mutant EGFRvIII and wild-type EGFR xenograft models, and is utilized for research on cancer [1].
In vivo
Depatuxizumab administered intraperitoneally (i.p.) at doses of 10 and 40 mg/kg three times per week for two weeks significantly inhibited tumor growth in the U87MG delta-2-7 glioblastoma (GBM) variant model and the A431 epidermoid carcinoma model in Nu/Nu mice [1]. The same treatment regimen with depatuxizumab suppressed tumor growth and levels of phosphorylated EGFR (pEGFR) in the EGFRvIII-positive GBM-SN0199-PDX model in NSG mice [1]. Moreover, depatuxizumab demonstrated dose-dependent inhibition of tumor growth in the SCC15 tumor-bearing SCID Beige mouse model when administered at concentrations ranging from 2 to 40 mg/kg [1].
AliasABT-806
Chemical Properties
Cas No.1471999-69-5
Storage & Solubility Information
StorageShipping with blue ice.

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TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
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