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Des His1, Glu8 Exendin-4
🥰Excellent
Catalog No. T76291
Des His1, Glu8 Exendin-4 is a glucagon-like peptide-1 receptor (GLP-1-R) antagonist that regulates blood glucose. Des His1, Glu8 Exendin-4 is used in the study of diabetes and obesity.
Des His1, Glu8 Exendin-4
🥰Excellent
Purity: 99.92%
Catalog No. T76291
Des His1, Glu8 Exendin-4 is a glucagon-like peptide-1 receptor (GLP-1-R) antagonist that regulates blood glucose. Des His1, Glu8 Exendin-4 is used in the study of diabetes and obesity.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $247 | In Stock | |
| 5 mg | $543 | In Stock | |
| 10 mg | $813 | In Stock | |
| 25 mg | $1,380 | In Stock | |
| 50 mg | $2,070 | In Stock | |
| 100 mg | $2,790 | In Stock |
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Purity:99.92%
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Product Introduction
Bioactivity
Chemical Properties
| Description | Des His1, Glu8 Exendin-4 is a glucagon-like peptide-1 receptor (GLP-1-R) antagonist that regulates blood glucose. Des His1, Glu8 Exendin-4 is used in the study of diabetes and obesity. |
| In vivo | After third ventricle injection of Des His1, Glu8 Exendin-4 (50 μg, 2 μl/15 s), a hyperglycemic response was observed in rats for the first 45 minutes after the intraperitoneal glucose load, and there was a significant increase in insulin levels and insulin area under the curve (AUC) during the IVGTT[1]. |
| Molecular Weight | 4063.46 |
| Formula | C179H277N47O59S |
| Smiles | [H]NCC(N[C@H](C(NCC(N[C@]([H])(C(N[C@@H](CC1=CC=CC=C1)C(N[C@]([H])(C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@@H](CCSC)C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@@H](C)C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@@H](CC2=CC=CC=C2)C(N[C@]([H])(C(N[C@H](C(N[C@@H](CC3=CNC4=C3C=CC=C4)C(N[C@H](C(N[C@H](C(N[C@H](C(NCC(NCC(N5CCC[C@H]5C(N[C@H](C(N[C@H](C(NCC(N[C@@H](C)C(N6CCC[C@H]6C(N7CCC[C@H]7C(N8CCC[C@H]8C(N[C@H](C(N)=O)CO)=O)=O)=O)=O)=O)=O)CO)=O)CO)=O)=O)=O)=O)CC(N)=O)=O)CCCCN)=O)CC(C)C)=O)=O)CCC(O)=O)=O)[C@@H](C)CC)=O)=O)CC(C)C)=O)CCCNC(N)=N)=O)C(C)C)=O)=O)CCC(O)=O)=O)CCC(O)=O)=O)CCC(O)=O)=O)=O)CCC(N)=O)=O)CCCCN)=O)CO)=O)CC(C)C)=O)CCC(O)=O)=O)CO)=O)[C@H](O)C)=O)=O)[C@H](O)C)=O)=O)CCC(O)=O)=O |
Storage & Solubility Information
| Storage | keep away from moisture,store at low temperature | Shipping with blue ice. |
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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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