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DL-TBOA
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Catalog No. T11055Cas No. 205309-81-5
Alias DLTBOA, DL TBOA
DL-TBOA is an inhibitor of excitatory amino acid transporter proteins, inhibiting excitatory amino acid transporter protein 1 (EAAT1), EAAT2, and EAAT3.
DL-TBOA
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Purity: 99.60%
Catalog No. T11055Alias DLTBOA, DL TBOACas No. 205309-81-5
DL-TBOA is an inhibitor of excitatory amino acid transporter proteins, inhibiting excitatory amino acid transporter protein 1 (EAAT1), EAAT2, and EAAT3.
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CitedSelect Batch
Purity:99.60%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | DL-TBOA is an inhibitor of excitatory amino acid transporter proteins, inhibiting excitatory amino acid transporter protein 1 (EAAT1), EAAT2, and EAAT3. |
| Targets&IC50 | EAAT2:6 μM, EAAT2 (human):5.7 μM, EAAT5:3.2 μM, EAAT1:70 μM, EAAT1 (human):42 μM (Ki), EAAT4:4.4 μM, EAAT3:6 μM |
| In vitro | In HCT116 and LoVo cell lines, DL-TBOA (70 μM, 350 μM; 48 hours) enhances SN38-induced cell death and counteracts Oxaliplatin-induced cell death[4]. |
| In vivo | In male Sprague-Dawley rats (180-250 g), DL-TBOA (1 nmol, 3 nmol, 10 nmol;i.c.v.) dose-dependently facilitated various somatic signs induced by Naloxone (0.1 mg/kg)[5]. |
| Alias | DLTBOA, DL TBOA |
| Molecular Weight | 239.22 |
| Formula | C11H13NO5 |
| Cas No. | 205309-81-5 |
| Smiles | [C@@H]([C@@H](C(O)=O)N)(OCC1=CC=CC=C1)C(O)=O |
| Relative Density. | 1.392 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||||||||||||
| Solubility Information | H2O: 2 mg/mL (8.36 mM), Sonication is recommended. DMSO: 100 mg/mL (418.00 mM), Sonication is recommended. | ||||||||||||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||||||||||||
H2O/DMSO
DMSO
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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