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Pack Size | Price | Availability | Quantity |
---|---|---|---|
2 mg | $92 | 5 days |
Description | DO34 is a highly potent and centrally active inhibitor of diacylglycerol lipase (IC50: 6 nM for DAGLα conversion of SAG to 2-AG). |
In vitro | DO34 also is a potent inhibitor of DAGLβ with IC50 of 3-8 nM [1]. |
In vivo | DO34 could block the tonic CB1 activation. DO34 prevents fasting-induced refeeding of mice, this is typical cannabinoid CB1-receptor-mediated behavior. DO34 decreases brain 2-AG levels in a dose- and time-dependent manner [2]. AM251 obviously increases basal PF-EPSCs in MAGL-TKO mice. The effect of AM251 is blocked by the DAGL inhibitor DO34 [3]. |
Molecular Weight | 531.53 |
Formula | C26H28F3N5O4 |
Cas No. | 1848233-58-8 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | |||||||||||||||||||||||||||||||||||
Solubility Information | DMSO: 100 mg/mL (188.14 mM) | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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