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Dostarlimab
🥰Excellent
Catalog No. T76850Cas No. 2022215-59-2
Alias TSR-042, TSR042, GSK-4057190A, GSK4057190A, ANB011, ANB 011
Dostarlimab (TSR-042) is a programmed cell death protein 1 (PD-1) receptor immune checkpoint inhibitor that blocks interactions with PD-L1 and PD-L2, used in the study of endometrial cancer.
Dostarlimab
Dostarlimab
🥰Excellent
Catalog No. T76850Alias TSR-042, TSR042, GSK-4057190A, GSK4057190A, ANB011, ANB 011Cas No. 2022215-59-2
Dostarlimab (TSR-042) is a programmed cell death protein 1 (PD-1) receptor immune checkpoint inhibitor that blocks interactions with PD-L1 and PD-L2, used in the study of endometrial cancer.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $263 | In Stock | |
| 5 mg | $689 | In Stock | |
| 10 mg | $1,080 | In Stock | |
| 25 mg | $1,630 | In Stock | |
| 50 mg | $2,180 | In Stock |
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Concentration:7.98 mg/mL
Purity:>95%
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Product Introduction
Bioactivity
Chemical Properties
| Description | Dostarlimab (TSR-042) is a programmed cell death protein 1 (PD-1) receptor immune checkpoint inhibitor that blocks interactions with PD-L1 and PD-L2, used in the study of endometrial cancer. |
| Targets&IC50 | PD-1 (human):2.0 nM (EC50) |
| In vitro | Dostarlimab has a strong binding affinity with human and cynomolateral monkey PD-1 protein with Kd of 0.3 and 0.5 nM, respectively. Dostarlimab binds to PD-1 on the surface of recombinant human and cynomophobe monkey cells expressed on CHO-K1 cells with EC50 values of 2.0 and 3.4 nM, respectively. Dostarlimab effectively blocked PD-1/PD-L1 and PD-1/PD-L2 binding with IC50 values of 1.8 and 1.5 nM, respectively. Adding Dostarlimab to the SEB-stimulated PBMC resulted in increased IL-2 production with an EC50 of about 0.1 nM, suggesting that Dostarlimab induced T cell activation. [1] |
| In vivo | Dostarlimab(200μg/ pill twice weekly) inhibited tumor growth in the MDA-MB-436 breast cancer model. [1] |
| Alias | TSR-042, TSR042, GSK-4057190A, GSK4057190A, ANB011, ANB 011 |
| Cas No. | 2022215-59-2 |
Storage & Solubility Information
| Storage | store at low temperature | store at -20°C | Shipping with blue ice. |
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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