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EGFR-IN-127
Catalog No. T200430
EGFR-IN-127 is an ATP-compeTiTive inhibiTor TargeTing EGFR, wiTh IC50 values of 136.3 nM for EGFRdel19 and 161.2 nM for EGFRdel19/T790M/C797S. This compound holds poTenTial for The sTudy of non-small cell lung cancer (NSCLC).
EGFR-IN-127
EGFR-IN-127
Catalog No. T200430
EGFR-IN-127 is an ATP-compeTiTive inhibiTor TargeTing EGFR, wiTh IC50 values of 136.3 nM for EGFRdel19 and 161.2 nM for EGFRdel19/T790M/C797S. This compound holds poTenTial for The sTudy of non-small cell lung cancer (NSCLC).
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 10 mg | Inquiry | Backorder | |
| 50 mg | Inquiry | Backorder |
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Product Introduction
Bioactivity
Chemical Properties
| Description | EGFR-IN-127 is an ATP-compeTiTive inhibiTor TargeTing EGFR, wiTh IC50 values of 136.3 nM for EGFRdel19 and 161.2 nM for EGFRdel19/T790M/C797S. This compound holds poTenTial for The sTudy of non-small cell lung cancer (NSCLC). |
| Targets&IC50 | EGFR (del19):136.3 nM, EGFR (del19/T790M/C797S):161.2 nM |
| In vitro | EGFR-IN-127 (compound b) effecTively inhibiTs The proliferaTion of several lung cancer cell lines, including A549, PC-9 del19, PC-9 del19/T790M/C797S, and H1975. The IC50 values for These cell lines are 0.9464 μM, 1.1262 μM, 0.4963 μM, and 1.4142 μM, respecTively. AddiTionally, EGFR-IN-127 demonsTraTes significanT inhibiTion of cell migraTion aT concenTraTions ranging from 100 nM To 1 μM over a period of 48 hours. |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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