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Endosidin-2

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Purity:98.29%

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COA HPLC HNMR

Endosidin-2

Catalog No. T37020Cas No. 1839524-44-5

Endosidin-2 is an exocyst inhibitor, a cell-permeable benzylidene benzoylhydrazine, that binds to the exocyst component of the 70 kDa (EXO70) subunit of the exocyst complex (Kd = 253 μM, EXO70A1).Endosidin-2 disrupts protein translocation between the endosomes and plasma membrane, thereby facilitating translocation of proteins to the vesicle for degradation. It also inhibits recirculation of endocytosed transferrin to the plasma membrane in HeLa cells and targets multiple isoforms of mammalian EXO70, leading to dysregulation of exocytosis.Endosidin2 can be used as a tool molecule to study cytosolization.

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Pack Size	Price	Availability
5 mg	$47	In Stock
10 mg	$89	In Stock
25 mg	$197	In Stock
50 mg	$322	In Stock
100 mg	$538	In Stock
500 mg	$1,150	In Stock
1 mL x 10 mM (in DMSO)	$52	In Stock

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Product Introduction

Bioactivity

Description	Endosidin-2 is an exocyst inhibitor, a cell-permeable benzylidene benzoylhydrazine, that binds to the exocyst component of the 70 kDa (EXO70) subunit of the exocyst complex (Kd = 253 μM, EXO70A1).Endosidin-2 disrupts protein translocation between the endosomes and plasma membrane, thereby facilitating translocation of proteins to the vesicle for degradation. It also inhibits recirculation of endocytosed transferrin to the plasma membrane in HeLa cells and targets multiple isoforms of mammalian EXO70, leading to dysregulation of exocytosis.Endosidin2 can be used as a tool molecule to study cytosolization.
In vitro	Endosidin2 (ES2) was utilized in studying polarized cell growth in the moss Physcomitrium patens , in which plants were exposed to increasing concentrations of ES2 with an IC50 between 8.8 and 12.3 µM. At 50 µM, tip-growing cells ruptured close to their tips, an indication that ES2 inhibits the deposition of new cell wall material via exocytosis.[2]
Alias	ES2, Endosidin 2

Chemical Properties

Molecular Weight	414.17
Formula	C15H12FIN2O3
Cas No.	1839524-44-5

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 90.0 mg/mL (217.3 mM)

DMF: 30 mg/mL

Ethanol: 0.25 mg/mL

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.4145 mL	12.0723 mL	24.1447 mL	120.7234 mL
5 mM	0.4829 mL	2.4145 mL	4.8289 mL	24.1447 mL
10 mM	0.2414 mL	1.2072 mL	2.4145 mL	12.0723 mL
20 mM	0.1207 mL	0.6036 mL	1.2072 mL	6.0362 mL
50 mM	0.0483 mL	0.2414 mL	0.4829 mL	2.4145 mL
100 mM	0.0241 mL	0.1207 mL	0.2414 mL	1.2072 mL

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