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Englerin A
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Catalog No. T38484Cas No. 1094250-15-3
Alias (-)-Englerin A
Englerin A, a TRPC4 and TRPC5 channel agonist, is a compound from the East African plant Phyllanthus engleri with analgesic, anti-inflammatory, and anticancer activities that induces necrosis in human renal cancer cells.
Englerin A
😃Good
Catalog No. T38484Alias (-)-Englerin ACas No. 1094250-15-3
Englerin A, a TRPC4 and TRPC5 channel agonist, is a compound from the East African plant Phyllanthus engleri with analgesic, anti-inflammatory, and anticancer activities that induces necrosis in human renal cancer cells.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 5 mg | Inquiry | Backorder |
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Product Introduction
Bioactivity
Chemical Properties
| Description | Englerin A, a TRPC4 and TRPC5 channel agonist, is a compound from the East African plant Phyllanthus engleri with analgesic, anti-inflammatory, and anticancer activities that induces necrosis in human renal cancer cells. |
| Targets&IC50 | TRPC5 (human):7.6 nM (EC50), TRPC4 (human):11.2 nM (EC50) |
| In vitro | Englerin A (50 nM) activates TRPC4/C5 channels, leading to an increase in intracellular calcium and membrane depolarization[3]. |
| In vivo | Athymic mice bearing 786-0 tumor xenografts were treated with Englerin A (5mg/kg i.p., daily except Sunday), and the results showed that Englerin A significantly inhibited tumor growth during the treatment period[4]. |
| Alias | (-)-Englerin A |
| Molecular Weight | 442.54 |
| Formula | C26H34O6 |
| Cas No. | 1094250-15-3 |
| Smiles | [H][C@@]12CC[C@@H](C)[C@@]1([H])[C@H](OC(=O)\C=C\c1ccccc1)[C@@]1(C[C@@H](OC(=O)CO)[C@@]2(C)O1)C(C)C |
Storage & Solubility Information
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||
| Solubility Information | Methanol: 20 mg/mL (45.19 mM), Sonication is recommended. | |||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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