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Galectin-3/galectin-8-IN-1
Catalog No. T79380
Galectin-3/galectin-8-IN-1 (Compound 53) serves as a dual inhibitor of the Galectin-3 and galectin-8 C-terminal domains, exhibiting dissociation constants (Kd) of 4.12 μM for Galectin-3 and 6.04 μM for galectin-8. It effectively impedes the migration of MRC-5 lung fibroblast cells and is utilized in cancer and tissue fibrosis research [1].
Galectin-3/galectin-8-IN-1
Galectin-3/galectin-8-IN-1
Catalog No. T79380
Galectin-3/galectin-8-IN-1 (Compound 53) serves as a dual inhibitor of the Galectin-3 and galectin-8 C-terminal domains, exhibiting dissociation constants (Kd) of 4.12 μM for Galectin-3 and 6.04 μM for galectin-8. It effectively impedes the migration of MRC-5 lung fibroblast cells and is utilized in cancer and tissue fibrosis research [1].
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CitedGalectin-3/galectin-8-IN-2
T79381
Galectin-3/galectin-8-IN-2 (Compound 57) is a dual inhibitor targeting the C-terminal domains of Galectin-3 and galectin-8, with dissociation constants (Kd) of 12.8 μM and 2.06 μM, respectively. It effectively inhibits MRC-5 lung fibroblast cell migration and serves as a potential research tool for studying cancer and tissue fibrosis [1].
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DB21, Galectin-1 Antagonist
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DB21, Galectin-1 Antagonist, is a peptidomimetic conjugated with dibenzofuran, serving as an allosteric inhibitor of galectin-1 (GAL1) interactions with glycans on cell surfaces. This compound enhances the inhibition of angiogenesis and tumor growth in melanoma, lung adenocarcinoma, and ovarian cancer models [1].
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Product Introduction
Bioactivity
Chemical Properties
| Description | Galectin-3/galectin-8-IN-1 (Compound 53) serves as a dual inhibitor of the Galectin-3 and galectin-8 C-terminal domains, exhibiting dissociation constants (Kd) of 4.12 μM for Galectin-3 and 6.04 μM for galectin-8. It effectively impedes the migration of MRC-5 lung fibroblast cells and is utilized in cancer and tissue fibrosis research [1]. |
| Molecular Weight | 518.39 |
| Formula | C22H13Cl2N3O4S2 |
Storage & Solubility Information
| Storage | Shipping with blue ice. |
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DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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