Shopping Cart
- Remove All
Your shopping cart is currently empty
Thiodigalactoside
🥰Excellent
Catalog No. T38074Cas No. 51555-87-4
Thiodigalactoside (TDG), a non-metabolizable disaccharide, serves as an orally active, potent galectin (GAL) inhibitor, exhibiting Kd values of 24 μM and 49 μM for GAL1 and GAL3, respectively. Demonstrating anti-inflammatory and anti-cancer properties, it significantly diminishes body weight gain in diet-induced obese rats.
Thiodigalactoside
🥰Excellent
Purity: 99.74%
Catalog No. T38074Cas No. 51555-87-4
Thiodigalactoside (TDG), a non-metabolizable disaccharide, serves as an orally active, potent galectin (GAL) inhibitor, exhibiting Kd values of 24 μM and 49 μM for GAL1 and GAL3, respectively. Demonstrating anti-inflammatory and anti-cancer properties, it significantly diminishes body weight gain in diet-induced obese rats.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 10 mg | $34 | In Stock | |
| 25 mg | $52 | In Stock | |
| 50 mg | Inquiry | In Stock | |
| 1 mL x 10 mM (in DMSO) | $33 | In Stock |
Bulk & Custom
Add to Cart
Questions
View MoreInhibitors Related to "Thiodigalactoside"
OTX008
PTX008, Calixarene 0118
T16413286936-40-1
OTX008 (PTX008) is a selective galectin-1 inhibitor.
- $64
Size
QTY
G3-C12 acetate(848301-94-0 free base)
T11346L
G3-C12 acetate shows anticancer activity. is a galectin-3 binding peptide, with Kd of 88 nM.
- $48
Size
QTY
GB1107
(2R,3R,4S,5R,6R)-2-(3,4-dichlorophenyl)sulfanyl-6-(hydroxymethyl)-4-[4-(3,4,5-trifluorophenyl)triazol-1-yl]oxane-3,5-diol
T153721978336-61-6
GB1107 is an effective and selective Galectin-3 inhibitor with a Kd of 37 nM.
- $53
Size
QTY
CitedSNAP 398299
SNAP-398299, SNAP398299
T28822903878-06-8In house
SNAP 398299 is a Glycopeptide Receptor Type 3 (Gal3) antagonist with anxiolytic and antidepressant-like effects and is used in the study of mood disorders.
- $1,520
Size
QTY
Galectin-3/galectin-8-IN-1
T79380
Galectin-3/galectin-8-IN-1 (Compound 53) serves as a dual inhibitor of the Galectin-3 and galectin-8 C-terminal domains, exhibiting dissociation constants (Kd) of 4.12 μM for Galectin-3 and 6.04 μM for galectin-8. It effectively impedes the migration of MRC-5 lung fibroblast cells and is utilized in cancer and tissue fibrosis research [1].
- Inquiry Price
Size
QTY
Galectin-3/galectin-8-IN-2
T79381
Galectin-3/galectin-8-IN-2 (Compound 57) is a dual inhibitor targeting the C-terminal domains of Galectin-3 and galectin-8, with dissociation constants (Kd) of 12.8 μM and 2.06 μM, respectively. It effectively inhibits MRC-5 lung fibroblast cell migration and serves as a potential research tool for studying cancer and tissue fibrosis [1].
- Inquiry Price
Size
QTY
DB21, Galectin-1 Antagonist
T826051623027-80-4
DB21, Galectin-1 Antagonist, is a peptidomimetic conjugated with dibenzofuran, serving as an allosteric inhibitor of galectin-1 (GAL1) interactions with glycans on cell surfaces. This compound enhances the inhibition of angiogenesis and tumor growth in melanoma, lung adenocarcinoma, and ovarian cancer models [1].
- Inquiry Price
Size
QTY
Galectin-3 antagonist 2
T745382921603-02-1
Galectin-3, a β-galactoside-specific carbohydrate recognition protein (lectin), facilitates the migration of B-cell precursor acute lymphoblastic leukemia (BCP-ALL) cells and demonstrates resistance to pharmaceutical interventions.
- $1,520
Size
QTY
Select Batch
Purity:99.74%
Contact us for more batch information
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | Thiodigalactoside (TDG), a non-metabolizable disaccharide, serves as an orally active, potent galectin (GAL) inhibitor, exhibiting Kd values of 24 μM and 49 μM for GAL1 and GAL3, respectively. Demonstrating anti-inflammatory and anti-cancer properties, it significantly diminishes body weight gain in diet-induced obese rats. |
| Targets&IC50 | GAL3:49 μM (Kd), GAL1:24 μM (Kd) |
| In vitro | Thiodigalactoside (TDG; 250 and 500 μM) demonstrates a dose-dependent decrease in fat accumulation, as evidenced by reductions in triglyceride (TG) content and Oil Red O (ORO) staining[1]. |
| In vivo | Thiodigalactoside (TDG; 5 mg/kg; IP; once per week for 5 weeks) significantly inhibits HFD-induced body weight gain, whereas oral administration (5 mg/kg; daily or weekly for 5 weeks) provides less reduction in body weight gain compared to IP administration [2]. |
| Molecular Weight | 358.36 |
| Formula | C12H22O10S |
| Cas No. | 51555-87-4 |
| Smiles | OC[C@H]1O[C@@H](S[C@@H]2O[C@H](CO)[C@H](O)[C@H](O)[C@H]2O)[C@H](O)[C@@H](O)[C@H]1O |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | PBS (pH 7.2): 10 mg/mL H2O: 90 mg/mL (251.1 mM), Sonication is recommended. DMF: 1 mg/mL DMSO: 50 mg/mL (139.52 mM)  | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO/H2O
| ||||||||||||||||||||||||||||||||||||
Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
Keywords
Preview
Related Tags: buy Thiodigalactoside | purchase Thiodigalactoside | Thiodigalactoside cost | order Thiodigalactoside | Thiodigalactoside chemical structure | Thiodigalactoside in vivo | Thiodigalactoside in vitro | Thiodigalactoside formula | Thiodigalactoside molecular weight
- TOP
Feedback
Hello! How can I help you today? 
Copyright © 2015-2024 TargetMol Chemicals Inc. All Rights Reserved.