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Thiodigalactoside

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Purity:99.74%

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COA HNMR HPLC

Thiodigalactoside

Catalog No. T38074Cas No. 51555-87-4

Thiodigalactoside (TDG), a non-metabolizable disaccharide, serves as an orally active, potent galectin (GAL) inhibitor, exhibiting Kd values of 24 μM and 49 μM for GAL1 and GAL3, respectively. Demonstrating anti-inflammatory and anti-cancer properties, it significantly diminishes body weight gain in diet-induced obese rats.

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Pack Size	Price	Availability
10 mg	$34	In Stock
25 mg	$52	In Stock
50 mg	Inquiry	In Stock
1 mL x 10 mM (in DMSO)	$33	In Stock

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Product Introduction

Bioactivity

Description	Thiodigalactoside (TDG), a non-metabolizable disaccharide, serves as an orally active, potent galectin (GAL) inhibitor, exhibiting Kd values of 24 μM and 49 μM for GAL1 and GAL3, respectively. Demonstrating anti-inflammatory and anti-cancer properties, it significantly diminishes body weight gain in diet-induced obese rats.
In vitro	Thiodigalactoside (TDG; 250 and 500 μM) demonstrates a dose-dependent decrease in fat accumulation, as evidenced by reductions in triglyceride (TG) content and Oil Red O (ORO) staining[1].
In vivo	Thiodigalactoside (TDG; 5 mg/kg; IP; once per week for 5 weeks) results in dramatic inhibition of HFD-induced body weight gain. Thiodigalactoside (5 mg/kg; oral; daily or weekly for 5 weeks) gave less reduction in body weight gain compare with i.p.[2].

Chemical Properties

Molecular Weight	358.36
Formula	C12H22O10S
Cas No.	51555-87-4

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

PBS (pH 7.2): 10 mg/mL

H2O: 90 mg/mL (251.1 mM)

DMF: 1 mg/mL

DMSO: 50 mg/mL (139.52 mM)

Solution Preparation Table

H2O/DMSO

	1mg	5mg	10mg	50mg
1 mM	2.7905 mL	13.9525 mL	27.9049 mL	139.5245 mL
5 mM	0.5581 mL	2.7905 mL	5.5810 mL	27.9049 mL
10 mM	0.2790 mL	1.3952 mL	2.7905 mL	13.9525 mL
20 mM	0.1395 mL	0.6976 mL	1.3952 mL	6.9762 mL
50 mM	0.0558 mL	0.2790 mL	0.5581 mL	2.7905 mL
100 mM	0.0279 mL	0.1395 mL	0.2790 mL	1.3952 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc