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GB1107

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Purity:98.33%

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COA HNMR HPLC

GB1107

Catalog No. T15372Cas No. 1978336-61-6

GB1107 is an effective and selective Galectin-3 inhibitor with a Kd of 37 nM.

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Pack Size	Price	Availability
1 mg	$53	In Stock
5 mg	$128	In Stock
10 mg	$189	In Stock
25 mg	$315	In Stock
50 mg	$468	In Stock
100 mg	$686	In Stock
1 mL x 10 mM (in DMSO)	$147	In Stock

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Product Introduction

Bioactivity

Description	GB1107 is an effective and selective Galectin-3 inhibitor with a Kd of 37 nM.
In vitro	GB1107 (0-1 μM) increases CD8+ T cell infiltration and tumor M1 macrophage polarization. GB1107 potentiates the effects of a PD-L1 immune checkpoint inhibitor to increase the expression of cytotoxic and apoptotic effector molecules including perforin-1, Fas ligand, IFN-γ, granzyme B, and cleaved caspase-3[1].
In vivo	In CD-1 nude female mice received 3x106 human lung adenocarcinoma cells (A549), GB1107 (10 mg/kg, p.o.) significantly reduces tumor growth and final tumor weights[1].
Alias	(2R,3R,4S,5R,6R)-2-(3,4-dichlorophenyl)sulfanyl-6-(hydroxymethyl)-4-[4-(3,4,5-trifluorophenyl)triazol-1-yl]oxane-3,5-diol

Chemical Properties

Molecular Weight	522.32
Formula	C20H16Cl2F3N3O4S
Cas No.	1978336-61-6

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 45 mg/mL (86.15 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.9145 mL	9.5727 mL	19.1454 mL	95.7268 mL
5 mM	0.3829 mL	1.9145 mL	3.8291 mL	19.1454 mL
10 mM	0.1915 mL	0.9573 mL	1.9145 mL	9.5727 mL
20 mM	0.0957 mL	0.4786 mL	0.9573 mL	4.7863 mL
50 mM	0.0383 mL	0.1915 mL	0.3829 mL	1.9145 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

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A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc