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gamma-DGG
Catalog No. T15369Cas No. 6729-55-1
Alias γ-D-Glutamylglycine, γDGG
gamma-DGG is a competitive blocker of AMPA receptor.
gamma-DGG
Catalog No. T15369Alias γ-D-Glutamylglycine, γDGGCas No. 6729-55-1
gamma-DGG is a competitive blocker of AMPA receptor.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 5 mg | $39 | 7-10 days | |
| 10 mg | $55 | 7-10 days |
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Product Introduction
Bioactivity
Chemical Properties
| Description | gamma-DGG is a competitive blocker of AMPA receptor. |
| In vitro | gamma-DGG (γ-DGG) is the most effective antagonist of the excitatory postsynaptic potentials (e.p.s.p.s). Its action is reversible and not associated with any change in the passive membrane properties of the granule cells or in the apparent reversal potential of the e.p.s.p.gamma-DGG blocks less at higher glutamate concentration. gamma-DGG (200-400 μM) in the bath decreases the miniature EPSC (mEPSC) amplitude by 26±2% (n=5 synapses) and shifts both the mEPSC amplitude distribution and the cumulative probability curve to the left [1]. The quantal analysis displays that the reduction in the e.p.s.p. paralleled the reduction in quantal size rather than quantal content, confirming a post-synaptic site of the action of gamma-DGG [2]. |
| Alias | γ-D-Glutamylglycine, γDGG |
| Molecular Weight | 204.18 |
| Formula | C7H12N2O5 |
| Cas No. | 6729-55-1 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | H2O: 150 mg/mL (734.65 mM) | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
H2O
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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