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gamma-DGG

Catalog No. T15369Cas No. 6729-55-1

gamma-DGG is a competitive blocker of AMPA receptor.

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Pack Size	Price	Availability	Quantity
5 mg	$39	7-10 days
10 mg	$55	7-10 days

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Product Introduction

Bioactivity

Description	gamma-DGG is a competitive blocker of AMPA receptor.
In vitro	gamma-DGG (γ-DGG) is the most effective antagonist of the excitatory postsynaptic potentials (e.p.s.p.s). Its action is reversible and not associated with any change in the passive membrane properties of the granule cells or in the apparent reversal potential of the e.p.s.p.gamma-DGG blocks less at higher glutamate concentration. gamma-DGG (200-400 μM) in the bath decreases the miniature EPSC (mEPSC) amplitude by 26±2% (n=5 synapses) and shifts both the mEPSC amplitude distribution and the cumulative probability curve to the left [1]. The quantal analysis displays that the reduction in the e.p.s.p. paralleled the reduction in quantal size rather than quantal content, confirming a post-synaptic site of the action of gamma-DGG [2].
Alias	γDGG, γ-D-Glutamylglycine

Chemical Properties

Molecular Weight	204.18
Formula	C7H12N2O5
Cas No.	6729-55-1

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

H2O: 150 mg/mL (734.65 mM)

Solution Preparation Table

H2O

	1mg	5mg	10mg	50mg
1 mM	4.8976 mL	24.4882 mL	48.9764 mL	244.8820 mL
5 mM	0.9795 mL	4.8976 mL	9.7953 mL	48.9764 mL
10 mM	0.4898 mL	2.4488 mL	4.8976 mL	24.4882 mL
20 mM	0.2449 mL	1.2244 mL	2.4488 mL	12.2441 mL
50 mM	0.0980 mL	0.4898 mL	0.9795 mL	4.8976 mL
100 mM	0.0490 mL	0.2449 mL	0.4898 mL	2.4488 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

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