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Pack Size | Price | Availability | Quantity |
---|---|---|---|
25 mg | $1,200 | 6-8 weeks | |
50 mg | $1,570 | 6-8 weeks | |
100 mg | $2,360 | 6-8 weeks |
Description | ATR inhibitor 2 is an orally active, ATP-competitive, and selective ATR inhibitor (Ki <150 pM) with antitumor activity. ATR inhibitor 2 potently inhibits ATR-driven phosphorylated checkpoint kinase-1 (Chk1) phosphorylation (IC50: 8 nM). |
Targets&IC50 | ATR:150 pM (ki) |
In vivo | In monotherapy efficacy studies ATR inhibitor 2 (VX-970, M6620) shows tumor stasis to regression in tumor models with alternative lengthening of telomeres (ALT). |
Alias | ATR inhibitor 2 |
Molecular Weight | 541.55 |
Formula | C25H29F2N9O3 |
Cas No. | 1613191-99-3 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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