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Gartisertib
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Catalog No. T10407Cas No. 1613191-99-3
Alias ATR inhibitor 2
ATR inhibitor 2 is an orally active, ATP-competitive, and selective ATR inhibitor (Ki <150 pM) with antitumor activity. ATR inhibitor 2 potently inhibits ATR-driven phosphorylated checkpoint kinase-1 (Chk1) phosphorylation (IC50: 8 nM).
Gartisertib
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Catalog No. T10407Alias ATR inhibitor 2Cas No. 1613191-99-3
ATR inhibitor 2 is an orally active, ATP-competitive, and selective ATR inhibitor (Ki <150 pM) with antitumor activity. ATR inhibitor 2 potently inhibits ATR-driven phosphorylated checkpoint kinase-1 (Chk1) phosphorylation (IC50: 8 nM).
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 25 mg | $1,200 | 6-8 weeks | |
| 50 mg | $1,570 | 6-8 weeks | |
| 100 mg | $2,360 | 6-8 weeks |
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Product Introduction
Bioactivity
Chemical Properties
| Description | ATR inhibitor 2 is an orally active, ATP-competitive, and selective ATR inhibitor (Ki <150 pM) with antitumor activity. ATR inhibitor 2 potently inhibits ATR-driven phosphorylated checkpoint kinase-1 (Chk1) phosphorylation (IC50: 8 nM). |
| Targets&IC50 | ATR:150 pM (ki) |
| In vivo | In monotherapy efficacy studies ATR inhibitor 2 (VX-970, M6620) shows tumor stasis to regression in tumor models with alternative lengthening of telomeres (ALT). |
| Alias | ATR inhibitor 2 |
| Molecular Weight | 541.55 |
| Formula | C25H29F2N9O3 |
| Cas No. | 1613191-99-3 |
| Relative Density. | 1.31g/cm3 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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